Arteriovenous malformation – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:15:48 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Arteriovenous malformation – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Safety and Effectiveness of Regorafenib for Patients with Arterio-Venous Malformations Unresponsive to Standard Treatment https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-regorafenib-for-patients-with-arterio-venous-malformations-unresponsive-to-standard-treatment/ Wed, 29 Apr 2026 15:04:35 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-regorafenib-for-patients-with-arterio-venous-malformations-unresponsive-to-standard-treatment/ This clinical trial is focused on studying a condition known as Arterio-Venous Malformations (AVMs). AVMs are abnormal connections between arteries and veins, which can lead to various complications. The trial is investigating the use of a medication called Regorafenib, which is taken as a film-coated tablet. This medication is being tested to see if it can help patients whose AVMs have not responded to standard treatments like surgery or embolization.

The purpose of the study is to evaluate the safety and effectiveness of Regorafenib in managing symptoms caused by AVMs. Participants in the study will take the medication orally and will be monitored over a period of time to assess any changes in their condition. The study aims to determine if Regorafenib can improve symptoms such as pain and the overall quality of life for those affected by these complex vascular anomalies.

Throughout the study, participants will undergo various assessments, including questionnaires about their quality of life and evaluations of their symptoms, particularly focusing on pain. Additionally, the size of the AVM lesions will be measured using imaging techniques like MRI and other scans. The study will also explore how the medication affects participants’ ability to perform daily activities. This trial is an important step in finding new ways to help those with AVMs that do not respond to existing treatments.

]]> Study on the Effectiveness of Apixaban for Pain Relief in Patients with Venous Malformations https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-apixaban-for-pain-relief-in-patients-with-venous-malformations/ Wed, 29 Apr 2026 15:01:35 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-apixaban-for-pain-relief-in-patients-with-venous-malformations/ This clinical trial is focused on studying the effects of the medication apixaban in patients who have a condition known as venous malformation. Venous malformations are abnormal clusters of blood vessels that can cause pain and other symptoms. In this study, the aim is to see how well apixaban can reduce pain in people with these malformations, especially when there is a problem with blood clotting inside the vessels, known as localized intravascular coagulation.

Participants in the study will receive either apixaban or a placebo. The study will compare the change in pain levels before and after eight weeks of treatment. Additionally, the study will look at changes in blood clotting, quality of life, and the number of blood clots in the venous malformations. The study will also monitor any bleeding episodes that occur during the treatment period.

The study will take place over several months, with an initial treatment phase lasting eight weeks. After this, there will be a follow-up period to assess changes in pain and quality of life three months after adjusting the dose of apixaban. The goal is to better understand how apixaban can help manage pain and improve the quality of life for those with venous malformations.

]]> Study on Enalapril for Adults with Painful Venous Malformations https://clinicaltrials.eu/trial/study-on-enalapril-for-adults-with-painful-venous-malformations/ Wed, 29 Apr 2026 14:28:24 +0000 https://clinicaltrials.eu/trial/study-on-enalapril-for-adults-with-painful-venous-malformations/ This clinical trial is focused on studying the effects of a medication called Enalapril on a condition known as venous malformations. Venous malformations are abnormal clusters of veins that can cause pain and discomfort. The study aims to explore how Enalapril, which is a type of medication known as an ACE-inhibitor, can help reduce the pain associated with these malformations.

Participants in the study will take Enalapril in the form of a tablet. The study will last for about 12 months, during which the participants’ pain levels and quality of life will be monitored. The study will also use MRI scans to observe any changes in the size of the venous malformations. Throughout the study, any side effects or adverse events will be recorded to ensure the safety of the participants.

The purpose of this study is to understand if Enalapril can effectively reduce pain and improve the quality of life for individuals with venous malformations. By the end of the study, researchers hope to gather valuable information that could lead to better treatment options for those affected by this condition.

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