Arrhythmia prophylaxis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:01:19 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Arrhythmia prophylaxis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Preventing Post-Operative Atrial Fibrillation with Botulinum Toxin Injections in Patients Undergoing Cardiac Surgery https://clinicaltrials.eu/trial/study-on-preventing-post-operative-atrial-fibrillation-with-botulinum-toxin-injections-in-patients-undergoing-cardiac-surgery/ Wed, 29 Apr 2026 14:59:48 +0000 https://clinicaltrials.eu/trial/study-on-preventing-post-operative-atrial-fibrillation-with-botulinum-toxin-injections-in-patients-undergoing-cardiac-surgery/ This clinical trial is focused on preventing a heart rhythm problem called atrial fibrillation that can occur after heart surgery. The study involves patients who are undergoing heart surgeries such as coronary artery bypass grafting, aortic valve repair, or surgery on the ascending aorta. The treatment being tested is an injection of Botulinum toxin, also known as Xeomin or IncobotulinumtoxinA, into specific fat pads around the heart’s pulmonary veins during surgery. This toxin is a protein that can affect nerve activity and is being studied for its potential to prevent atrial fibrillation after surgery.

The purpose of the study is to determine if these injections can effectively prevent atrial fibrillation in the weeks following heart surgery. Participants in the study will receive either the Botulinum toxin injection or a placebo, which is a substance with no active medication. The study will monitor the heart rhythm of participants for three weeks after their surgery to see if the treatment helps reduce the occurrence of atrial fibrillation.

Throughout the study, participants will have their heart rhythm checked regularly using devices like a Holter monitor and daily heart monitoring. The results will be reviewed by cardiologists to assess the effectiveness of the treatment. This research aims to find a new way to help patients recover from heart surgery with fewer complications related to heart rhythm.

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