Aortic valve replacement – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:34:25 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Aortic valve replacement – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on High vs. Low Dose Bupivacaine Hydrochloride and Epinephrine for Pain Relief After Aortic Valve Replacement Surgery https://clinicaltrials.eu/trial/study-on-high-vs-low-dose-bupivacaine-hydrochloride-and-epinephrine-for-pain-relief-after-aortic-valve-replacement-surgery/ Wed, 29 Apr 2026 14:57:04 +0000 https://clinicaltrials.eu/trial/study-on-high-vs-low-dose-bupivacaine-hydrochloride-and-epinephrine-for-pain-relief-after-aortic-valve-replacement-surgery/ This clinical trial is focused on patients undergoing minimally invasive heart valve surgery, specifically those having an aortic valve replacement. The study is investigating the effectiveness of a pain management technique called the serratus anterior plane block, which is a type of local anesthesia. The treatment being tested involves two different doses of a medication called Marcaine, which contains the active substances bupivacaine hydrochloride and epinephrine. These substances are used to numb the area and reduce pain after surgery.

The purpose of the study is to see if using a higher dose of this local anesthesia can reduce the need for additional pain medication, such as opioids, after surgery. Participants in the study will be randomly assigned to receive either a high dose or a low dose of the anesthesia. The study will monitor how much additional pain medication is needed, as well as the level of pain experienced by patients, their satisfaction with pain management, and their recovery process, including how quickly they can move around after surgery.

Throughout the study, various aspects of recovery will be assessed, such as the time it takes for patients to be ready to leave the intensive care unit, their overall satisfaction with pain relief, and their quality of life after surgery. The study aims to provide valuable information on how to improve pain management for patients undergoing heart valve surgery, potentially leading to better recovery experiences and outcomes.

]]> Study on Pain Relief Using Levobupivacaine, Sodium Chloride, and Piritramide for Patients Undergoing Minimally Invasive Aortic Valve Replacement https://clinicaltrials.eu/trial/study-on-pain-relief-using-levobupivacaine-sodium-chloride-and-piritramide-for-patients-undergoing-minimally-invasive-aortic-valve-replacement/ Wed, 29 Apr 2026 14:28:00 +0000 https://clinicaltrials.eu/trial/study-on-pain-relief-using-levobupivacaine-sodium-chloride-and-piritramide-for-patients-undergoing-minimally-invasive-aortic-valve-replacement/ This clinical trial is focused on studying the effects of a specific pain management technique for patients undergoing a type of heart surgery known as minimally invasive aortic valve replacement. This surgery is performed through a small incision in the chest, called a right anterior minithoracotomy. The trial aims to compare the pain relief provided by a method called the interpectoral-pectoserratus plane block with a control group that receives a sham block. The main goal is to see how well this pain management technique works in reducing the need for pain medication after surgery.

The study involves the use of three different medications. The first is Levobupivacaine, which is a local anesthetic used to numb the area and reduce pain. The second is Sodium Chloride, commonly known as salt water, which is used as a standard solution for infusion. The third is Piritramide, a pain-relieving medication that is administered intravenously. These medications are used to help manage pain and improve recovery after the surgery.

Participants in the study will be randomly assigned to receive either the interpectoral-pectoserratus plane block or a sham block. The trial will monitor various aspects of recovery, including the amount of pain medication needed, the level of pain experienced, and any complications that may arise. The study will also assess the overall quality of life and recovery process for patients after surgery. The trial is expected to continue until the end of 2027, with recruitment starting in March 2024.

]]> Study on Empagliflozin for Patients with Aortic Stenosis After Aortic Valve Replacement https://clinicaltrials.eu/trial/study-on-empagliflozin-for-patients-with-aortic-stenosis-after-aortic-valve-replacement/ Wed, 29 Apr 2026 14:26:14 +0000 https://clinicaltrials.eu/trial/study-on-empagliflozin-for-patients-with-aortic-stenosis-after-aortic-valve-replacement/ This clinical trial is focused on studying the effects of a medication called Jardiance (empagliflozin) in patients who have undergone an aortic valve replacement (AVR). The study is particularly interested in patients with a condition known as aortic stenosis, which is a narrowing of the heart’s aortic valve that can lead to serious heart problems. The purpose of the study is to determine if Jardiance can help reduce the size of the heart’s left ventricle, which is the main pumping chamber, and improve symptoms in patients after they have had their aortic valve replaced.

Participants in the study will be randomly assigned to receive either Jardiance or a placebo. A placebo is a substance with no active medication, used to compare the effects of the actual drug. The study will monitor changes in the heart’s left ventricle over a period of 12 months after the aortic valve replacement. This will be done using imaging techniques like computed tomography (CT) and echocardiography, which are methods to take detailed pictures of the heart. The study will also look at other factors such as heart function and levels of a heart-related protein called NT-proBNP.

The trial aims to provide valuable information on whether Jardiance can offer additional benefits to patients recovering from aortic valve replacement surgery. By understanding these effects, the study hopes to improve treatment options and outcomes for individuals with aortic stenosis who undergo this type of heart surgery.

]]> Study on Lowering INR to Reduce Bleeding in Patients with Mechanical Aortic Valves Using Warfarin, Acenocoumarol, and Phenprocoumon https://clinicaltrials.eu/trial/study-on-lowering-inr-to-reduce-bleeding-in-patients-with-mechanical-aortic-valves-using-warfarin-acenocoumarol-and-phenprocoumon/ Wed, 29 Apr 2026 14:26:00 +0000 https://clinicaltrials.eu/trial/study-on-lowering-inr-to-reduce-bleeding-in-patients-with-mechanical-aortic-valves-using-warfarin-acenocoumarol-and-phenprocoumon/ This clinical trial is focused on patients who have undergone a mechanical bileaflet aortic valve replacement and are being treated with a Vitamin K Antagonist. The study aims to evaluate the safety and effectiveness of maintaining a lower INR (International Normalized Ratio) range in these patients. The INR is a measure used to determine the clotting tendency of blood, which is important for patients with mechanical heart valves to prevent complications such as blood clots or bleeding.

The trial involves the use of medications such as Warfarin, Acenocoumarol, and Phenprocoumon, which are all types of Vitamin K Antagonists. These medications help to thin the blood and prevent clot formation. Participants in the study will be randomly assigned to receive one of these medications or a placebo. The study will monitor the participants over a period of up to 36 months to observe any occurrences of blood clots, strokes, or bleeding events.

The purpose of the study is to determine if a lower INR range can safely reduce the risk of bleeding while still effectively preventing blood clots in patients with mechanical heart valves. Throughout the study, participants will have regular check-ups to monitor their health and the effects of the medication. The study will also track other health outcomes such as overall survival, any type of stroke, heart attacks, and other related conditions. This research is important to improve the management of patients with mechanical heart valves and to enhance their quality of life.

]]>