Aortic valve disease – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:13:40 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Aortic valve disease – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of Colchicine Treatment to Slow Down Aortic Valve Stenosis Progression in Adult Patients with Moderate Disease https://clinicaltrials.eu/trial/study-on-colchicine-for-slowing-aortic-valve-stenosis-in-patients-with-moderate-aortic-stenosis/ Wed, 29 Apr 2026 15:02:11 +0000 https://clinicaltrials.eu/trial/study-on-colchicine-for-slowing-aortic-valve-stenosis-in-patients-with-moderate-aortic-stenosis/ This study focuses on patients with Aortic Valve Stenosis, a heart condition where the aortic valve becomes narrow and stiff due to calcium buildup, making it harder for blood to flow from the heart to the rest of the body. The study will test whether colchicine, a medication given as tablets, can slow down the progression of this condition compared to placebo.

The purpose of the study is to determine if colchicine treatment can reduce the progression of moderate aortic valve stenosis by decreasing inflammation and calcium buildup in the heart valve. Participants in this study will receive either colchicine tablets or placebo tablets for approximately 24 months.

The study will use various imaging techniques to monitor changes in the heart valve over time, including computed tomography scans to measure calcium buildup, echocardiography (ultrasound of the heart) to assess blood flow through the valve, and positron emission tomography to evaluate valve activity. The study is designed so that neither the participants nor the researchers will know who is receiving which treatment.

]]> Study on the Effects of Oxycodone and Paracetamol in Patients with Heart Valve or Coronary Artery Disease After Cardiac Surgery https://clinicaltrials.eu/trial/study-on-the-effects-of-oxycodone-and-paracetamol-in-patients-with-heart-valve-or-coronary-artery-disease-after-cardiac-surgery/ Wed, 29 Apr 2026 14:58:58 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-oxycodone-and-paracetamol-in-patients-with-heart-valve-or-coronary-artery-disease-after-cardiac-surgery/ This clinical trial is focused on patients who have undergone heart surgery, specifically those with conditions like coronary artery disease, aortic valve disease, mitral valve disease, tricuspid valve disease, or a combination of these. The study is investigating the effects of a medication called oxycodone, which is used for pain relief. Oxycodone will be administered through a method called PCA, or patient-controlled analgesia, which allows patients to manage their pain by controlling the amount of medication they receive.

The purpose of the study is to evaluate how oxycodone affects breathing after heart surgery. Researchers will monitor patients’ oxygen levels and breathing patterns to understand any changes that occur with the use of oxycodone. The study will also look at how much oxycodone is used and its concentration in the blood. Additionally, the study will assess pain levels, any complications from surgery, and overall quality of life after the surgery.

Participants in the study will receive either oxycodone or a placebo. The study will take place over a period of time, with regular check-ins to monitor the effects of the medication. The goal is to gather information on both the short-term and long-term outcomes of using oxycodone for pain management after heart surgery.

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