Aortic aneurysm – European Clinical Trials Information Network

Study of Carbon Dioxide versus Iodine Contrast in Patients with Abdominal Aortic Aneurysm Having Fenestrated Endovascular Repair

Wed, 29 Apr 2026 15:07:58 +0000

This study is looking at abdominal aortic aneurysm, which is a bulging or swelling in the main blood vessel that carries blood from the heart down through the abdomen. The study involves patients who are planned to have a procedure called fenestrated endovascular aneurysm repair, which is a way to fix this bulging blood vessel from the inside using special tubes and devices. During this procedure, doctors need to see the blood vessels clearly, and they typically use iodine contrast media, which are special liquids that help make blood vessels visible on imaging scans. The study will use different types of iodine contrast products including iohexol, iomeprol, and iodixanol, which are all injected into the blood vessels to help with imaging.

The purpose of the study is to find out if using less iodine contrast during the procedure by using carbon dioxide gas instead when possible can reduce kidney problems after the surgery compared to the usual approach. Kidney problems can sometimes happen after this type of procedure because the contrast material can affect how the kidneys work. The study will compare two different strategies: one that tries to use carbon dioxide for imaging whenever possible to reduce the amount of iodine contrast needed, and one that uses the standard amount of iodine contrast.

During the study, patients will be randomly assigned to receive one of these two imaging strategies during their planned procedure. The doctors will monitor kidney function by checking blood tests and urine output after the surgery to see if there are any signs of kidney injury. Patients will be followed for up to three years after the procedure with regular check-ups, imaging scans, and questionnaires about their quality of life and recovery. The study will also track other important outcomes such as the success of the surgery, any complications that occur, survival rates, and changes in kidney function over time.

Study on Metformin Embonate to Slow Growth of Small Abdominal Aortic Aneurysms in Patients Without Diabetes

Wed, 29 Apr 2026 14:57:59 +0000

This clinical trial is focused on studying the effects of the medication metformin on a condition known as a small abdominal aortic aneurysm (AAA). An abdominal aortic aneurysm is a bulge in the wall of the main blood vessel that carries blood from the heart to the rest of the body. This study is specifically looking at small aneurysms, which are under active surveillance and measure 30-49 mm in diameter for men and 30-44 mm for women.

The purpose of the study is to investigate whether taking 2 grams of metformin daily for five years can slow down the growth rate of these small aneurysms in patients who do not have diabetes. Participants will be monitored over this period, with assessments at the start, after 24 months, and at the end of the study. The study will also look at whether metformin can limit the increase in the size of the aneurysm, improve quality of life, and reduce the need for surgery.

Throughout the study, the safety of metformin will be closely monitored, with particular attention to any side effects or unexpected effects on the aneurysm. The study will also explore if there is a relationship between the dose or duration of metformin treatment and its effects, as well as its impact on inflammation and tissue changes around the blood vessel. An interim analysis will be conducted at 24 months to evaluate safety and effectiveness.

Study on Abdominal Aortic Aneurysm Treatment with Allogeneic Adipose-Derived Mesenchymal Stem Cells for Patients Undergoing Endovascular Repair

Wed, 29 Apr 2026 14:56:56 +0000

This clinical trial is focused on studying the treatment of an abdominal aortic aneurysm, a condition where a large blood vessel in the abdomen becomes enlarged and can potentially burst. The treatment being tested involves the use of allogeneic adipose-derived mesenchymal stem cells, which are special cells taken from donated fat tissue and expanded in a lab. These cells are then injected into the aneurysm area to see if they can help stabilize it.

The purpose of the study is to evaluate the safety and feasibility of using these stem cells in patients who are undergoing a procedure called endovascular surgical repair, which is a less invasive surgery to fix the aneurysm. Participants in the study will receive either the stem cell treatment or a placebo. The study will monitor participants for any side effects related to the procedure or the stem cells, as well as any major heart or brain-related events within a year after treatment.

Throughout the study, the size of the aneurysm will be checked using imaging tests like CT scans and Doppler echo. The study will also compare the results to past patients who did not receive the stem cell treatment. Other aspects being observed include the movement of the stent used in the repair, any leaks, the need for additional surgeries, hospital admissions, and changes in quality of life. The study is expected to continue until early 2026.