Anxiety – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:19:19 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Anxiety – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Comparison of Oxazepam 50 mg orodispersible tablets and Oxazepam 50 mg standard tablets in healthy volunteers to test if they work the same way in the body https://clinicaltrials.eu/trial/comparison-of-oxazepam-50-mg-orodispersible-tablets-and-oxazepam-50-mg-standard-tablets-in-healthy-volunteers-to-test-if-they-work-the-same-way-in-the-body/ Wed, 29 Apr 2026 15:07:14 +0000 https://clinicaltrials.eu/trial/comparison-of-oxazepam-50-mg-orodispersible-tablets-and-oxazepam-50-mg-standard-tablets-in-healthy-volunteers-to-test-if-they-work-the-same-way-in-the-body/ This clinical trial compares two forms of oxazepam, a medication belonging to the benzodiazepine group of drugs. The study evaluates how the body processes a new orodispersible tablet form (dissolves in the mouth) compared to the standard tablet form of oxazepam. One medication is called Oxazepam 50 mg orodispersible tablets, and the other is Seresta 50 mg tablets.

The purpose of this study is to determine if both forms of the medication work similarly in the body. The study uses a crossover design, which means participants will receive both forms of the medication at different times. Both medications contain the same active ingredient and the same strength of 50 mg.

During the study, healthy participants will take a single dose of each medication form. Blood samples will be collected to measure how much of the medication enters the bloodstream and how long it stays in the body. The study also looks at how well participants tolerate the orodispersible tablet and monitors for any side effects. This is not a treatment study for any specific medical condition but rather a comparison of two different forms of the same medication.

]]> Study on the Bioequivalence of Oxazepam 10 mg Orodispersible Tablets Compared to Standard Tablets in Healthy Volunteers https://clinicaltrials.eu/trial/study-on-the-bioequivalence-of-oxazepam-10-mg-orodispersible-tablets-compared-to-standard-tablets-in-healthy-volunteers/ Wed, 29 Apr 2026 15:05:51 +0000 https://clinicaltrials.eu/trial/study-on-the-bioequivalence-of-oxazepam-10-mg-orodispersible-tablets-compared-to-standard-tablets-in-healthy-volunteers/ This clinical trial is focused on comparing two forms of the medication Oxazepam, which is commonly used to treat anxiety. The study involves Oxazepam 10 mg orodispersible tablets and Seresta 10 mg tablets. The purpose of the study is to compare how the body absorbs these two forms of the medication and to determine if they are equivalent in terms of their effects.

The study is designed as a single-dose, open-label trial, meaning that participants will know which form of the medication they are taking. It involves healthy individuals who will receive both forms of the medication at different times. Participants will take the medication orally, and the study will observe how the body processes each form. The trial will also assess the safety of the medications by monitoring any side effects and checking vital signs, such as heart rate and blood pressure.

Additionally, the study will evaluate the taste and ease of use of the orodispersible tablet form. This involves placing the tablet on the tongue and assessing its palatability shortly after. The trial aims to provide valuable information on whether the two forms of Oxazepam are interchangeable, which could help inform future treatment options for patients requiring this medication.

]]> Title: Evaluation of nasal remimazolam and lidocaine for sedation and anxiety in adults: Testing comfort and effectiveness of nasal spray delivery https://clinicaltrials.eu/trial/study-on-the-sedative-effects-of-nasal-remimazolam-and-lidocaine-for-patients-with-anxiety/ Wed, 29 Apr 2026 15:05:39 +0000 https://clinicaltrials.eu/trial/study-on-the-sedative-effects-of-nasal-remimazolam-and-lidocaine-for-patients-with-anxiety/ This study examines the effects of remimazolam, a medication used for sedation, in people with stress and anxiety. The purpose is to evaluate how well this medicine works and how comfortable it is when given as a nasal spray.

The treatment involves using a special nasal spray device to deliver two doses of remimazolam. Before giving remimazolam, participants will receive lidocaine (a numbing medicine) through the same type of nasal spray to prevent discomfort in the nose. The total amount of remimazolam used will be 40 milligrams, given as two separate 20-milligram doses.

During the study, medical staff will monitor how sleepy participants become and how they feel after receiving the medication. They will track these effects for several hours after the medication is given. This will help determine if giving remimazolam as a nasal spray could be an effective way to provide sedation.

]]> Study on the Effects of Yohimbine and Hydrocortisone on Stress and Moral Decisions in Military Personnel https://clinicaltrials.eu/trial/study-on-the-effects-of-yohimbine-and-hydrocortisone-on-stress-and-moral-decisions-in-military-personnel/ Wed, 29 Apr 2026 15:05:38 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-yohimbine-and-hydrocortisone-on-stress-and-moral-decisions-in-military-personnel/ This clinical trial is focused on understanding how certain medications affect decision-making under stress. The study involves the use of two medications: yohimbine hydrochloride and hydrocortisone. These medications are being tested to see how they influence moral judgment, particularly in situations that mimic an acute stress response, which is a sudden and intense stress reaction that can occur in challenging situations.

The purpose of the study is to observe the effects of these medications on moral judgment in military personnel. Participants will be given either yohimbine, hydrocortisone, or a placebo. The study will monitor how these medications affect the choices made during tasks that measure moral judgment, such as deciding between different ethical options. The study will also look at how these medications impact working memory, impulse control, and risk-taking behavior.

Participants will take the medications in the form of tablets or oral powder, and the study will last for a short period. The goal is to better understand how stress and these medications can influence decision-making processes. This research could provide valuable insights into how stress affects ethical decisions and help develop strategies to manage stress in high-pressure environments.

]]> Study on the Effects of Sertraline on Anxiety and Depression in Heart Failure Patients with Preserved Ejection Fraction https://clinicaltrials.eu/trial/study-on-the-effects-of-sertraline-on-anxiety-and-depression-in-heart-failure-patients-with-preserved-ejection-fraction/ Wed, 29 Apr 2026 15:02:16 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-sertraline-on-anxiety-and-depression-in-heart-failure-patients-with-preserved-ejection-fraction/ This clinical trial is focused on studying the effects of the medication sertraline on patients who have heart failure with preserved ejection fraction and are experiencing anxiety-depressive symptoms. Heart failure with preserved ejection fraction is a condition where the heart’s ability to pump blood is not as effective as it should be, but the heart’s pumping capacity is still within normal limits. Sertraline is a medication commonly used to treat depression and anxiety. In this study, some participants will receive sertraline, while others will receive a placebo.

The purpose of the study is to understand how sertraline affects anxiety and depression symptoms, as well as certain heart-related health markers, in people with this type of heart failure. Participants will be monitored over a period of time to see if there are any changes in their symptoms or health status. The study will also look at how sertraline might impact the time it takes for participants to be hospitalized for heart-related issues or any other cause, as well as the time to any cause of death.

Throughout the study, participants will undergo regular assessments to track their mental health using tools like the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) scale. These assessments will help determine any changes in anxiety and depression levels. Additionally, the study will evaluate other health indicators, such as biomarkers related to the function of blood vessels, to gain a comprehensive understanding of sertraline’s effects on heart health and mental well-being in these patients.

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