Antibiotic therapy – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Sat, 20 Jun 2026 04:03:32 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Antibiotic therapy – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Post-Surgery Antibiotic Use in Patients with Complicated Acute Appendicitis: Evaluating Metronidazole, Ceftriaxone, and Ofloxacin Hydrochloride https://clinicaltrials.eu/trial/study-on-post-surgery-antibiotic-use-in-patients-with-complicated-acute-appendicitis-evaluating-metronidazole-ceftriaxone-and-ofloxacin-hydrochloride/ Wed, 29 Apr 2026 14:57:31 +0000 https://clinicaltrials.eu/trial/study-on-post-surgery-antibiotic-use-in-patients-with-complicated-acute-appendicitis-evaluating-metronidazole-ceftriaxone-and-ofloxacin-hydrochloride/ This clinical trial is focused on studying the effects of post-operative antibiotic therapy in patients who have undergone a laparoscopic appendectomy for a condition known as complicated acute appendicitis. This condition involves inflammation of the appendix that may include complications such as a perforated appendix, which means the appendix has burst, or the presence of abscesses, which are collections of pus. The study aims to evaluate the impact of not using antibiotics after surgery on the rate of infections that occur in the area of the surgery.

The trial involves several medications, including metronidazole, glucose, ceftriaxone sodium, lidocaine hydrochloride, and ofloxacin hydrochloride. These medications are administered through infusion, which means they are given directly into the bloodstream. The study also includes a group that receives a placebo, which is a substance with no active medication, to compare the effects of the antibiotics.

Participants in the study will be monitored for a period of up to three days after their surgery. The main focus is to observe the occurrence of infections at the surgical site within 30 days after the operation. Additionally, the study will look at other factors such as the quality of life before and after surgery, the number of days without antibiotics, and the balance between antibiotic use and resistance to bacteria. The goal is to understand whether antibiotics are necessary after surgery for this type of appendicitis and to ensure the best outcomes for patients.

]]> Study on the Effects of Saccharomyces boulardii CNCM I-745 and Amoxicillin on Gut Health in Patients with Early Lyme Disease Undergoing Antibiotic Treatment https://clinicaltrials.eu/trial/study-on-the-effects-of-saccharomyces-boulardii-cncm-i-745-and-amoxicillin-on-gut-health-in-patients-with-early-lyme-disease-undergoing-antibiotic-treatment/ Wed, 29 Apr 2026 14:30:36 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-saccharomyces-boulardii-cncm-i-745-and-amoxicillin-on-gut-health-in-patients-with-early-lyme-disease-undergoing-antibiotic-treatment/ This clinical trial is focused on studying the effects of a probiotic treatment on the gut health of patients who are receiving antibiotic therapy for a condition known as erythema migrans, which is an early skin form of Lyme disease. The treatment being tested is called Saccharomyces boulardii CNCM I-745, a type of beneficial yeast that is often used to support gut health. The study will also involve the use of an antibiotic called amoxicillin, which is commonly prescribed to treat bacterial infections, including those associated with Lyme disease. Additionally, some participants will receive a placebo, which looks like the treatment but contains no active ingredients.

The purpose of the study is to understand how Saccharomyces boulardii CNCM I-745, either alone or in combination with amoxicillin, affects the gut microbiota, which is the community of microorganisms living in the intestines. Participants in the study will take the treatments orally in the form of capsules. The study will last for a period of up to 21 days, during which time participants will be monitored for changes in their gut health and any side effects they may experience.

Throughout the study, participants will be asked to keep a diary of their bowel movements and any symptoms they experience. This information will help researchers assess the impact of the treatments on gut health and the occurrence of antibiotic-associated diarrhea. The study aims to provide valuable insights into how probiotics like Saccharomyces boulardii CNCM I-745 can support gut health during antibiotic treatment for conditions such as erythema migrans.

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