The purpose of this study is to check if gadopiclenol works well for finding and tracking perianal fistulas when used during magnetic resonance imaging, which is also called MRI, a type of scan that uses magnets and radio waves to create detailed pictures of the inside of the body. Participants will receive both contrast agents at different times during the study, with each one being given through a vein before an MRI scan is performed. The study follows a crossover design, which means that each person will have scans with both contrast agents so that doctors can compare how well each one works in showing the fistula tract, which is the path or tunnel of the abnormal connection.

During the study, doctors will look at the MRI images to see how clearly they can identify the perianal fistula when each contrast agent is used. They will also measure technical aspects of the images, such as how much difference there is between the fistula and the healthy tissue around it, and how much the contrast agent brightens the fistula area compared to before it was given. This information will help determine if gadopiclenol is as effective as gadobutrol for this specific use in people with Crohn’s disease and perianal fistulas.

The trial involves the use of two antibiotics: Metronidazole and Ciprofloxacin. These are both commonly used medications that help fight bacterial infections. Participants in the study will receive either these antibiotics or a placebo, which looks like the real medication but does not contain any active ingredients. The purpose of the study is to determine if the antibiotics can effectively prevent the development of perianal fistulas after the surgical drainage of the abscess.

Participants in the study will be randomly assigned to receive either the antibiotics or the placebo. The study will be conducted over a period of time, with follow-up assessments to monitor the development of any fistulas and to evaluate other factors such as quality of life, the need for additional procedures, and any complications. The goal is to gather information that could improve treatment outcomes for individuals with perianal abscesses.

In addition to the regenerative cells, the study will also use medications such as Metronidazole and Cefuroxime, which are antibiotics that help fight infections. The purpose of the study is to evaluate how well this combination of treatments works in healing the fistulas and improving the quality of life for patients. The study will compare the use of ADRC and ADRC001 to see which is more effective and will also look at how these treatments affect the body’s immune response.

Participants in the study will receive the treatment and be monitored over a period of time to assess the healing of the fistulas. The study will measure the healing rate at six and twelve months, as well as the impact on the patient’s quality of life and anal continence. The study will also investigate the risk factors for the recurrence of the fistulas and use MRI scans to check for any remaining fistula or fluid collection. The goal is to find a more effective way to treat perianal fistulas and improve patient outcomes.

The purpose of the study is to evaluate the safety of giving this treatment more than once to patients who have already received it before. Participants in the study will receive a repeat administration of Darvadstrocel, and the study will monitor them over a long period to check for any side effects or complications. The study will also look at how well the treatment works in closing the fistulas and preventing them from reopening. This will be assessed at various points in time, such as 6 weeks, 24 weeks, and up to 156 weeks after the treatment is given again.

Throughout the study, participants will undergo regular check-ups and assessments, including MRI scans, to ensure the treatment is working effectively and to monitor for any new issues. The study aims to provide valuable information on the safety and effectiveness of using Darvadstrocel for treating complex perianal fistulas in people with Crohn’s Disease, helping to improve future treatment options for this challenging condition.

The purpose of the study is to explore how effective infliximab is when added to the usual surgical treatment for complex anal fistulas that are not related to Crohn’s disease. Participants in the study will receive treatment over a period of time, and their progress will be monitored to see if the fistulas improve enough to allow for surgical closure. The study will also look at changes in the activity of the fistulas and any complications that might arise from the medical treatment.

Throughout the study, participants will undergo regular assessments, including evaluations of their quality of life and the activity of the fistulas using methods like MRI scans. The study aims to gather information over several months to determine the long-term effectiveness of the treatment and to see if it can lead to healing of the fistulas. The ultimate goal is to find a more effective way to manage and treat complex anal fistulas, improving the quality of life for those affected by this condition.

The purpose of the study is to evaluate how effective and safe Darvadstrocel is in treating these fistulas. Participants in the study will receive the treatment and be monitored over a period of 24 weeks, with an additional follow-up period extending up to 52 weeks. During this time, doctors will check if the fistulas are healing and if there are any side effects from the treatment. Some participants may receive a placebo, which is a substance with no active medication, to compare the results.

The study aims to see if the treatment can help close the fistulas and reduce symptoms, improving the quality of life for those affected. The trial will involve regular check-ups and assessments, including the use of MRI scans to monitor the condition of the fistulas. The ultimate goal is to find a safe and effective treatment option for young patients dealing with this challenging aspect of Crohn’s Disease.

The purpose of the study is to see how well the 68Ga-FAPi-46 PET-CT scan can show and measure the activity of fibroblasts, which are cells involved in the healing process, during the early stages of healing in perianal Crohn’s fistulas. Participants in the study will undergo imaging at the start and at different times during the study to track changes. The study will help researchers understand how the healing process can be monitored using this imaging technique.

Throughout the study, the researchers will collect visual and quantitative data from the imaging to assess how the fistulas are healing over time. This information will be compared with other clinical assessments to provide a comprehensive view of the healing process. The study aims to improve understanding of how to monitor and potentially enhance the treatment of perianal Crohn’s fistulas using advanced imaging methods.