Anaesthetic complication neurological – European Clinical Trials Information Network

Effect of Dexmedetomidine vs Sodium Chloride on Emergence Delirium in Children Aged 1‑7 Years Undergoing Adenotonsillectomy

Wed, 27 May 2026 04:05:21 +0000

The trial looks at children aged 1‑7 who are having adenotonsillectomy, a surgery to remove the adenoids and tonsils to improve breathing. The condition being studied is emergence delirium, a confused and restless state that can happen when a child wakes up from anesthesia. The study will test whether the medication dexmedetomidine can lower the chance of this problem compared with a placebo that contains sodium chloride. The purpose is to see if this drug reduces the risk of emergence delirium in this setting.

Children are randomly assigned to receive either the study drug or the placebo during the operation. The anesthesia team uses heart rate variability and electroencephalography to guide how deep the anesthesia is. After surgery, the child’s behavior is checked at 15, 30 and 45 minutes after waking using the PAEDs score and simple pain scales to see if delirium or pain is present. The length of stay in the recovery area and any side effects are also recorded.

Study of flumazenil for preventing emergence delirium in children after ear, nose and throat surgery

Wed, 29 Apr 2026 15:08:17 +0000

This study examines pediatric emergence delirium, which is a condition where children become confused, agitated, or distressed when waking up from anesthesia. This condition can occur in children after they have undergone ear, nose, and throat surgery. The study will use flumazenil, a medication that reverses the effects of another drug called midazolam, which is commonly used to help patients relax before and during surgery. The comparison treatment in this study is sodium chloride, which is a salt water solution. Both medications will be given by injection.

The purpose of this study is to find out whether using flumazenil affects how often children experience confusion and agitation when waking up from anesthesia after ear, nose, and throat procedures. The study will involve children between three and seven years old who are having ear, nose, and throat surgery. During the study, children will receive either flumazenil or the salt water solution to reverse the relaxing effects of midazolam that was given before their surgery.

After the surgery is completed and the child wakes up, the medical team will observe and record whether the child shows signs of confusion or agitation in the recovery room. The observations will continue until the child is ready to leave the recovery room. The study will compare how often these symptoms occur in children who received flumazenil versus those who received the salt water solution.

Evaluating the effects of intravenous melatonin for preventing agitation and emergence delirium in children undergoing elective surgery

Wed, 29 Apr 2026 14:58:01 +0000

This clinical trial focuses on studying emergence delirium, a condition where children experience confusion, agitation, and distress when waking up from general anesthesia after surgery. The study will test whether melatonin, a substance that helps regulate sleep and wake cycles, can prevent this condition when given through an intravenous injection during surgery.

The study will involve children undergoing planned surgical procedures. During the surgery, participants will receive either melatonin or a placebo through their intravenous line. The medication will be combined with sodium chloride solution, which is commonly used for delivering medications through veins.

The research aims to determine if melatonin can safely prevent agitation and confusion in children as they wake up from anesthesia. The study will also look at how much pain medication children need after surgery and monitor for any side effects of the treatment. This is a carefully controlled study where neither the medical staff nor the patients will know which treatment is being given.