Alexander disease – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:32:20 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Alexander disease – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of ION373 Given by Spinal Injection for Patients with Alexander Disease https://clinicaltrials.eu/trial/study-on-the-effects-of-ion373-in-patients-with-alexander-disease/ Wed, 29 Apr 2026 14:29:00 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-ion373-in-patients-with-alexander-disease/ This study focuses on patients with Alexander Disease, a rare genetic condition that affects the nervous system. The research evaluates a new medication called ION373, which is given through an injection into the spinal fluid. The medication is designed to target a specific protein that is involved in the disease process.

The study tests how well ION373 works in improving or stabilizing movement abilities in people with Alexander Disease. Some participants will receive the actual medication, while others will receive a placebo. The medication or placebo will be given through injections into the space around the spinal cord, known as intrathecal administration.

During the study, participants will receive the treatment for 61 weeks. The researchers will monitor how well participants can walk and move, along with other symptoms related to Alexander Disease. They will also check the safety of the treatment and measure certain substances in the spinal fluid to understand how the medication works in the body.

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