Acne – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 16 Jun 2026 04:02:14 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Acne – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of N-Acetyl-GED-0507-34-LEVO 5% gel applied daily for 12 weeks in patients with acne vulgaris https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-n-acetyl-ged-0507-34-levo-gel-for-patients-with-acne-vulgaris/ Mon, 04 May 2026 07:57:52 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-n-acetyl-ged-0507-34-levo-gel-for-patients-with-acne-vulgaris/ This study investigates a new treatment for acne vulgaris, a common skin condition that causes spots and pimples on the face and sometimes on the upper body. The study will test a new medication called N-Acetyl-GED-0507-34-Levo gel 5%, which is applied directly to the skin, comparing it with a vehicle gel (a gel without the active medication).

The purpose of this research is to determine how well this new gel works and how safe it is for treating acne when used once daily for 12 weeks. The treatment involves applying the gel to affected areas of the face, and if needed, to the upper chest, shoulders, and upper back areas that can be reached for self-application.

During the study, participants will use either the treatment gel or vehicle gel once daily for 12 weeks. Healthcare providers will monitor changes in acne by counting the number of different types of spots and evaluating the overall appearance of the skin. They will also check for any skin reactions or other effects that might occur during treatment. The study will track how the treatment affects participants’ quality of life and overall well-being.

]]> Study of Topical Donepezil Hydrochloride Cream for Safety and Effectiveness in Adult Patients with Acne Vulgaris https://clinicaltrials.eu/trial/study-of-topical-donepezil-hydrochloride-cream-for-safety-and-effectiveness-in-adult-patients-with-acne-vulgaris/ Wed, 29 Apr 2026 15:07:45 +0000 https://clinicaltrials.eu/trial/study-of-topical-donepezil-hydrochloride-cream-for-safety-and-effectiveness-in-adult-patients-with-acne-vulgaris/ This study is looking at acne vulgaris, which is a common skin condition that causes pimples and blemishes on the face. The treatment being tested is called AT-004, which is a cream that contains donepezil hydrochloride as its active ingredient. Some people in the study will receive the actual AT-004 cream while others will receive a placebo cream that looks the same but does not contain the active medicine. The purpose of this study is to find out if AT-004 cream is safe to use on the skin and if it works to improve acne.

During the study, participants will apply the cream to their face for a period of 12 weeks. The study doctors will check the skin for any side effects and will count the number of pimples to see if the treatment is working. These checks will happen at the beginning of the study and then again after 4 weeks, 8 weeks, and 12 weeks. The doctors will also take pictures of the acne at these visits to track any changes. Blood tests and other safety checks will be done to make sure the treatment is not causing any problems in the body.

The study will also look at how the treatment affects the quality of life of people with acne by using a questionnaire. In a small group of participants, the doctors will measure how much of the medicine gets into the bloodstream when applied to the skin. The study will compare results between people who use the AT-004 cream and those who use the placebo cream to determine if the treatment makes a difference in clearing acne and reducing both red, swollen pimples and blackheads or whiteheads.

]]> Study on the Effectiveness of Clindamycin and Tretinoin Gel for Treating Acne in Patients https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-clindamycin-and-tretinoin-gel-for-treating-acne-in-patients/ Wed, 29 Apr 2026 15:03:55 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-clindamycin-and-tretinoin-gel-for-treating-acne-in-patients/ This clinical trial is focused on studying the treatment of acne vulgaris, a common skin condition that causes pimples and spots, especially on the face. The study will compare two different gels that contain the active ingredients clindamycin and tretinoin. These ingredients are often used to treat acne by reducing bacteria and promoting skin cell turnover. The trial will involve three groups: one using the test product, Clindamycin + Tretinoin/Verisfield gel, another using the reference product, Acnatac®/Meda gel, and a third group using a placebo.

The purpose of the study is to determine if the test product is as effective as the reference product in treating acne. Participants will apply the gel to their face for a period of 12 weeks. During this time, changes in the number of acne lesions, which include both inflamed spots like papules and pustules, and non-inflamed spots like open and closed comedones, will be monitored. The study aims to show that both the test and reference products are better than the placebo in reducing acne symptoms.

Throughout the study, participants will be observed for any side effects, such as skin reactions like redness, dryness, or itching. The study will also track any serious or non-serious adverse effects that may occur. The goal is to ensure the safety and effectiveness of the treatment for those suffering from acne vulgaris.

]]> Study of N-Acetyl-GED-0507-34-LEVO gel 5% applied daily for treating acne vulgaris https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-n-acetyl-ged-0507-34-levo-gel-for-patients-with-acne-vulgaris/ Wed, 29 Apr 2026 14:59:08 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-n-acetyl-ged-0507-34-levo-gel-for-patients-with-acne-vulgaris/ This clinical trial studies the effectiveness and safety of a new topical medication for treating acne vulgaris, a common skin condition that causes pimples, blackheads, and whiteheads on the face and body. The study tests N-Acetyl-GED-0507-34-Levo gel 5%, which is applied to the skin once daily, comparing it to a placebo gel over a period of 12 weeks.

The study focuses on treating acne on both the face and trunk (upper chest, shoulders, and upper back) areas. The medication is being tested to see how well it reduces different types of acne lesions, including inflammatory lesions (red, swollen bumps) and non-inflammatory lesions (blackheads and whiteheads). The study will measure changes in the number of acne lesions and overall improvement in skin appearance.

Throughout the study, participants will have their acne assessed using standardized scoring systems. The research team will monitor the skin’s response to treatment and any potential side effects. The study also includes evaluations of how acne affects quality of life using special questionnaires. Safety monitoring includes checking for skin reactions at the application site, such as redness, peeling, dryness, stinging, burning, or itching.

]]> Title: Long-term safety study of N-Acetyl-GED-0507-34-LEVO gel 5% applied to the skin for patients with acne vulgaris https://clinicaltrials.eu/trial/study-on-long-term-safety-of-n-acetyl-ged-0507-34-levo-gel-for-patients-with-acne-vulgaris/ Wed, 29 Apr 2026 14:58:42 +0000 https://clinicaltrials.eu/trial/study-on-long-term-safety-of-n-acetyl-ged-0507-34-levo-gel-for-patients-with-acne-vulgaris/ This study examines the long-term safety and effectiveness of a new topical medication for acne vulgaris, a common skin condition that causes pimples, blackheads, and whiteheads on the face and body. The medication being tested is N-Acetyl-GED-0507-34-Levo gel 5%, which is applied to the skin once daily.

The study aims to determine how safe and effective this gel treatment is when used for up to 52 weeks (one year) in people with acne. The medication will be applied to affected areas on the face, and in some cases, it may also be used on the upper chest, shoulders, and upper back areas where acne is present.

During the study, participants will have regular check-ups where doctors will monitor their skin’s response to the treatment. They will assess changes in acne severity, count the number of acne lesions, and keep track of any side effects. The study will also evaluate how the treatment affects participants’ quality of life. Throughout the study, doctors will monitor participants’ overall health through physical examinations and laboratory tests.

]]> Study Comparing Isotretinoin with Doxycycline, Tretinoin, and Adapalene for Moderate Acne in Patients with Skin of Color https://clinicaltrials.eu/trial/study-comparing-isotretinoin-with-doxycycline-tretinoin-and-adapalene-for-moderate-acne-in-patients-with-skin-of-color/ Wed, 29 Apr 2026 14:47:51 +0000 https://clinicaltrials.eu/trial/study-comparing-isotretinoin-with-doxycycline-tretinoin-and-adapalene-for-moderate-acne-in-patients-with-skin-of-color-2/ This clinical trial is focused on studying the treatment of acne, a common skin condition that causes pimples and spots, particularly on the face. The study will compare the effectiveness of an oral medication called isotretinoin with other standard treatments currently used for moderate acne in individuals with skin of color. The goal is to determine if starting treatment with isotretinoin earlier can better reduce the severity of acne-related skin changes over a six-month period.

Participants in the study will receive either isotretinoin or one of the standard treatments, which may include medications like doxycycline, tretinoin cream, adapalene cream, or lymecycline. The study will last for up to six months, during which time participants will be asked to take selfies of their facial skin to monitor changes. These images will be analyzed using a special algorithm designed to assess the severity of acne and any related skin pigmentation issues.

The study will also look at other factors, such as the number and type of acne lesions, any side effects experienced, and the overall quality of life of participants. This information will help researchers understand the benefits and risks of using isotretinoin compared to other treatments for moderate acne in people with darker skin tones. The trial aims to provide valuable insights into the most effective ways to manage acne and improve skin health in this population.

]]> Study on the Effectiveness and Safety of Clindamycin and Tretinoin Gel for Patients with Papulopustular Acne https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-clindamycin-and-tretinoin-gel-for-patients-with-papulopustular-acne/ Wed, 29 Apr 2026 14:30:16 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-clindamycin-and-tretinoin-gel-for-patients-with-papulopustular-acne/ This clinical trial is focused on studying the effects of a new treatment for papulopustular acne, a common skin condition characterized by red, inflamed bumps and pimples. The study will compare the effectiveness and safety of a new gel containing Clindamycin and Tretinoin against an existing treatment called Acnatac and a placebo. Clindamycin is an antibiotic that helps reduce bacteria and inflammation, while Tretinoin is a form of vitamin A that helps the skin renew itself more quickly.

The purpose of the study is to determine how well the new gel works in reducing the number of acne lesions over a period of 12 weeks. Participants will be randomly assigned to use either the new gel, the existing treatment, or a placebo. The study will involve regular visits to monitor the skin’s response to the treatment and to ensure the safety of all participants. The treatment will be applied to the skin, and the progress will be assessed by counting the number of acne lesions at different points during the study.

Throughout the study, both the participants and the researchers will not know which treatment each participant is receiving, which is known as a “double-blind” study. This helps ensure that the results are not biased. The study aims to provide valuable information on the potential benefits of the new gel in treating papulopustular acne and to compare its effectiveness with the existing treatment and a placebo. Participants will be closely monitored for any side effects or changes in their skin condition during the study period.

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