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Suxamethonium Chloride Dihydrate

This article discusses the use of Suxamethonium Chloride Dihydrate in clinical trials, particularly focusing on its application in pediatric anesthesia for orthopedic trauma surgery. The drug, also known as Succinylcholine, is being studied as part of a broader investigation into preventing persistent postoperative pain in children through the use of locoregional analgesia techniques.

Table of Contents

What is Suxamethonium Chloride Dihydrate?

Suxamethonium Chloride Dihydrate is a medication used in medical procedures, particularly during surgeries. It belongs to a class of drugs known as neuromuscular blocking agents[1]. This medication is also referred to as Suxamethonium or Succinylcholine.

Medical Uses

Suxamethonium is primarily used in anesthesia. Its main purpose is to cause short-term paralysis of the muscles, which is particularly useful during certain medical procedures[1]. Some common scenarios where Suxamethonium might be used include:

  • To facilitate endotracheal intubation (inserting a breathing tube)
  • During short surgical procedures that require muscle relaxation
  • In emergency situations where rapid muscle paralysis is needed

How is it Administered?

Suxamethonium Chloride Dihydrate is administered via intravenous injection or infusion. This means it’s given directly into a vein[1]. The specific product mentioned in the clinical trial data is “SUXAMETHONIUM AGUETTANT 10 mg/mL, solution injectable en seringue préremplie,” which translates to “Suxamethonium Aguettant 10 mg/mL, solution for injection in a pre-filled syringe.”

Dosage Information

The dosage of Suxamethonium is carefully calculated by healthcare professionals based on various factors including the patient’s weight, age, and the specific medical procedure. According to the clinical trial information, the maximum daily dose is 1 mg/kg (milligram per kilogram of body weight)[1]. It’s important to note that this medication should only be administered by trained medical personnel in a controlled setting.

Other Names for Suxamethonium

Suxamethonium Chloride Dihydrate is known by several other names, which include[1]:

  • Succinylcholine chloride dihydrate
  • Succinylcholine dichloride dihydrate
  • Suxamethonium dichloride dihydrate

Precautions and Considerations

While Suxamethonium is an effective and widely used medication in anesthesia, there are several important considerations:

  • It should only be used under the supervision of trained anesthesiologists or other qualified healthcare professionals.
  • The medication causes temporary muscle paralysis, including the muscles used for breathing. Therefore, patients receiving this medication will need assistance with breathing during its effects.
  • It’s classified as an auxiliary medication in the clinical trial context, meaning it’s used to support the main treatment or procedure rather than being the primary focus of the study[1].
  • As with any medication, there can be potential side effects or contraindications. These should be discussed with your healthcare provider if you’re scheduled for a procedure where Suxamethonium might be used.

Remember, Suxamethonium Chloride Dihydrate is a specialized medication used in specific medical contexts. If you have any questions or concerns about its use in your medical care, always consult with your healthcare provider for personalized information and advice.

Aspect Details
Study Drug Suxamethonium Chloride Dihydrate (SUXAMETHONIUM AGUETTANT 10 mg/mL)
Study Population Children aged 5 to under 15 years and 3 months
Medical Condition Post-operative pain after orthopedic trauma surgery
Main Objective Evaluate locoregional analgesia for preventing persistent postoperative pain
Study Design Randomized trial with two arms: Locoregional Analgesia + general anesthesia vs. General anesthesia alone
Primary Endpoint Pain measurement using Numerical Rating Scale at 3 months post-surgery
Key Secondary Endpoints Neuropathic pain, immediate post-operative pain, opioid consumption
Drug Administration Intravenous bolus injection/IV infusion
Maximum Daily Dose 1 mg/kg

FAQ

  • What is Suxamethonium Chloride Dihydrate used for in these clinical trials? In these trials, Suxamethonium Chloride Dihydrate is used as part of the general anesthesia procedure for children undergoing orthopedic trauma surgery. It's being studied in combination with locoregional analgesia techniques to potentially prevent persistent postoperative pain.
  • What age group is being studied in this clinical trial? The clinical trial is focusing on children aged 5 years to just under 15 years and 3 months old who require surgical treatment of a fracture by osteosynthesis.
  • What are the main objectives of the study? The main objective is to demonstrate the positive impact of locoregional analgesia in preventing persistent postoperative pain after orthopedic trauma surgery in children. Secondary objectives include comparing neuropathic pain, immediate post-operative pain, and opioid consumption between different treatment groups.
  • How is the effectiveness of the treatment being measured? The primary measure of effectiveness is pain assessment using a Numerical Rating Scale (NRS) 3 months after surgery. Secondary measures include neuropathic pain screening, immediate post-operative pain scores, and the presence of pain at 6 and 12 months post-surgery.
  • What are some exclusion criteria for this study? Some key exclusion criteria include known allergy to Mepivacaine, atrioventricular conduction disorders, sensory neurological deficit of the operated limb, ischemia of the operated limb, and patients on anticoagulant drugs. Additionally, polytrauma patients and those with uncontrolled epilepsy are excluded from the study.

Ongoing Clinical Trials on Suxamethonium Chloride Dihydrate

  • Study on Preventing Persistent Postoperative Pain in Children Using Mepivacaine Hydrochloride and Drug Combination

    Recruiting

    3 1 1 1
    Investigated drugs:
    France

Glossary

  • Suxamethonium Chloride Dihydrate: A muscle relaxant drug used in general anesthesia, also known as Succinylcholine. It causes short-term paralysis and is often used to help with the insertion of breathing tubes.
  • Locoregional Analgesia: A pain relief technique that involves injecting local anesthetics near nerves to numb a specific area of the body, reducing pain during and after surgery.
  • Osteosynthesis: A surgical procedure to stabilize and join the ends of fractured (broken) bones by mechanical devices such as metal plates, pins, rods, wires or screws.
  • Neuropathic Pain: Pain caused by damage or disease affecting the nervous system. It's often described as burning, stabbing, or shooting pain.
  • Numerical Rating Scale (NRS): A pain assessment tool where patients rate their pain intensity from 0 (no pain) to 10 (worst possible pain).
  • Post-Interventional Monitoring Room: A specialized area where patients are closely monitored immediately after surgery or other medical procedures.
  • Titration: The process of gradually adjusting the dose of a medication until the desired effect is achieved.
  • Atrioventricular Conduction Disorders: Problems with the heart's electrical system that can affect the rate and rhythm of the heartbeat.

References

  1. http://clinicaltrials.eu/trial/study-on-preventing-persistent-postoperative-pain-in-children-using-mepivacaine-hydrochloride-and-drug-combination/