#1 Clinical Trials Search in Europe

Methylprednisolone Acetate

This article summarizes several clinical trials investigating the use of methylprednisolone acetate, a corticosteroid medication, for treating different medical conditions. The trials examine its effectiveness compared to other treatments for issues like inflammation after eye surgery, gout attacks, carpal tunnel syndrome, and back pain. Understanding these studies can provide insights into potential treatment options for patients with these conditions.

Table of Contents

What is Methylprednisolone Acetate?

Methylprednisolone Acetate is a type of steroid medication that belongs to the class of drugs known as corticosteroids. It is also known by brand names such as Depo-Medrol[1]. This medication is a synthetic (man-made) version of hormones naturally produced by the adrenal glands. It works by reducing inflammation and suppressing the immune system, which can be beneficial in treating various medical conditions[2].

Medical Uses

Methylprednisolone Acetate is used to treat a variety of conditions characterized by inflammation or overactive immune responses. Some of the conditions it’s commonly used for include:

  • Carpal Tunnel Syndrome: A condition causing numbness and tingling in the hand and arm[3]
  • Gout: A type of arthritis characterized by sudden, severe attacks of pain, swelling, redness and tenderness in joints[1]
  • Lumbar Spine Disc Herniation and Radiculitis: Conditions affecting the lower back and causing pain that may radiate to the legs[2]
  • Post-operative Inflammation: Inflammation following surgical procedures, such as cataract surgery[4]

How is it Administered?

Methylprednisolone Acetate is typically administered as an injection. The method of injection can vary depending on the condition being treated:

  • Intramuscular (IM) Injection: The medication is injected directly into a muscle. For example, in the treatment of gout, a dose of 120mg may be given as an IM injection[1].
  • Intracarpal Injection: For conditions like carpal tunnel syndrome, the medication may be injected directly into the affected area of the wrist[3].
  • Epidural Injection: In cases of back pain or disc herniation, the medication may be injected into the space around the spinal cord[2].

Effectiveness

Methylprednisolone Acetate has been shown to be effective in reducing inflammation and pain in various conditions. For instance:

  • In lumbar spine conditions, it has been found to provide pain relief lasting from one week up to one year[2].
  • For post-operative inflammation in cataract surgery, it has been shown to effectively control inflammation[4].

Potential Side Effects

While Methylprednisolone Acetate can be effective, it’s important to be aware of potential side effects. These may include:

  • Worsening of diabetes
  • Increased blood pressure
  • Effects on heart disease

These side effects are particularly important to consider in patients with kidney disease or other underlying health conditions[1].

Comparisons with Other Medications

Methylprednisolone Acetate is often compared to other medications in clinical trials:

  • Vs. Dexamethasone: Both are used in epidural injections for back pain, but their effectiveness may differ[2].
  • Vs. Ozone Therapy: In treating carpal tunnel syndrome, methylprednisolone acetate is being compared to ozone injections[3].
  • Vs. Anakinra: For gout treatment, especially in patients with kidney disease, methylprednisolone is being compared to anakinra, a newer medication that targets a specific inflammatory pathway[1].

Use in Special Populations

Methylprednisolone Acetate requires special consideration in certain patient groups:

  • Patients with Kidney Disease: The use of this medication in patients with chronic kidney disease is being studied, as these patients may be more susceptible to side effects[1].
  • Diabetic Patients: Care should be taken when using this medication in diabetic patients, as it can affect blood sugar levels[5].
Condition Methylprednisolone Acetate Use Comparison Treatment Key Findings
Post-operative eye inflammation Eye drops (as Pred Forte or EconoPred Plus) Generic prednisolone acetate 1% Generic prednisolone acetate 1% found to be less effective
Gout attacks in chronic kidney disease Intramuscular injection (Depo-Medrone) Anakinra (subcutaneous injection) Comparison of efficacy and safety in progress
Carpal tunnel syndrome in scleroderma Local injection Ozone therapy Comparison of pain relief and nerve conduction parameters
Lumbar back pain Epidural injection (Depo-Medrol) Dexamethasone Comparison of pain relief and functional outcomes
Macular edema in diabetic retinopathy after cataract surgery Eye drops (Prednisolone Acetate 1%) Dexamethasone intracanalicular insert Comparison of effectiveness in preventing macular edema

FAQ

  • What is methylprednisolone acetate used for in these clinical trials? In these trials, methylprednisolone acetate is used to treat inflammation after eye surgery, gout attacks in patients with kidney disease, carpal tunnel syndrome in scleroderma patients, and lumbar back pain.
  • How is methylprednisolone acetate administered in these studies? Depending on the study, methylprednisolone acetate is administered in various ways, including as eye drops, intramuscular injections, or local injections into affected areas like the carpal tunnel or lumbar spine.
  • What are some alternative treatments being compared to methylprednisolone acetate? Some alternatives being compared include other steroid formulations like prednisolone acetate and dexamethasone, as well as non-steroid treatments like anakinra (for gout) and ozone therapy (for carpal tunnel syndrome).
  • What are the main outcomes being measured in these trials? The trials measure various outcomes including reduction of inflammation, pain relief, improvement in function, changes in disease markers, and safety profiles of the treatments.
  • Are there any special patient populations being studied? Yes, some trials focus on specific patient groups such as those with chronic kidney disease, scleroderma patients, and diabetic patients undergoing cataract surgery.

Ongoing Clinical Trials on Methylprednisolone Acetate

  • Study on Gene Therapy GNT0003 for Patients with Severe Crigler-Najjar Syndrome Requiring Phototherapy

    Recruiting

    2 1 1 1
    Investigated diseases:
    Investigated drugs:
    France Italy The Netherlands

  • Study on Percutaneous Needle Fasciotomy with Methylprednisolone Acetate or Saline for Dupuytren’s Contracture in the Finger Joint

    Recruiting

    3 1 1
    Investigated diseases:
    Investigated drugs:
    Denmark

  • Study of rituximab followed by cladribine for patients with relapsing-remitting multiple sclerosis with less than 10 years disease duration

    Not yet recruiting

    2 1 1 1
    Investigated diseases:
    Investigated drugs:
    Sweden

  • Study on the Effectiveness of N-Acetylcysteine and Methylprednisolone for Patients with Severe Acute Alcoholic Hepatitis

    Not yet recruiting

    3 1 1 1
    Investigated drugs:
    Spain

  • Study on Severe Erythema Multiforme: Comparing Methylprednisolone Acetate and Lidocaine Hydrochloride Monohydrate with Placebo for Hospitalized Patients

    Not yet recruiting

    3 1 1
    Investigated diseases:
    Investigated drugs:
    France

  • Study on the Safety of ATA-200 Gene Therapy for Patients with Limb-Girdle Muscular Dystrophy Type R5

    Not yet recruiting

    2 1 1 1
    Investigated diseases:
    Investigated drugs:
    France Italy

  • Continued Access Study for Patients with Neurological Disease Using Ocrelizumab and Drug Combination

    Not yet recruiting

    3 1 1 1
    Investigated drugs:
    Czechia France Germany

  • Study on High-Dose Methylprednisolone and Prednisolone for Children with Stroke Due to Focal Cerebral Arteriopathy

    Not yet recruiting

    3 1 1 1
    Investigated drugs:
    Austria Denmark France Germany Sweden

  • Study on the Long-Term Safety of Isatuximab for Adults with Multiple Myeloma Benefiting from Isatuximab Therapy

    Not recruiting

    2 1 1 1
    Investigated diseases:
    Investigated drugs:
    Czechia Finland France Greece Italy Spain +1

  • Study Comparing Acasunlimab and Pembrolizumab with Docetaxel for Patients with Metastatic Non-Small Cell Lung Cancer After Previous Treatments

    Not recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    Austria Belgium Bulgaria Croatia Estonia France +9

Glossary

  • Methylprednisolone acetate: A synthetic corticosteroid medication used to reduce inflammation in various conditions. It's a more potent form of prednisone.
  • Corticosteroid: A class of steroid hormones produced in the adrenal cortex or made synthetically. They are used to reduce inflammation in many conditions.
  • Intramuscular injection: A technique of delivering medication by injecting it directly into a muscle.
  • Carpal tunnel syndrome: A condition that causes numbness, tingling, and other symptoms in the hand and arm due to a compressed nerve in the wrist.
  • Scleroderma: A group of rare diseases that involve hardening and tightening of the skin and connective tissues.
  • Gout: A form of arthritis characterized by severe pain, redness, and tenderness in joints, often starting in the big toe.
  • Chronic kidney disease: A condition characterized by gradual loss of kidney function over time.
  • Anakinra: A medication that blocks the action of interleukin-1, a substance in the body that causes inflammation.
  • Ozone therapy: A form of alternative medicine that introduces ozone into the body to treat various conditions.
  • Cataract: A clouding of the lens in the eye that affects vision, common in older adults.
  • Macular edema: Swelling or thickening of the macula, the part of the eye responsible for detailed central vision.
  • Diabetic retinopathy: A diabetes complication that affects the eyes, potentially leading to vision loss.

References

  1. https://clinicaltrials.gov/study/NCT02578394
  2. https://clinicaltrials.gov/study/NCT01397552
  3. https://clinicaltrials.gov/study/NCT03742466
  4. https://clinicaltrials.gov/study/NCT01227876
  5. https://clinicaltrials.gov/study/NCT04362241