#1 Clinical Trials Search in Europe

Glycerol

Clinical trials investigating Glycerol focus on how this treatment is used in specific patient groups and what benefits it may provide. The studies look at outcomes such as bowel function and quality of life in people with low anterior resection syndrome. They also compare Glycerol suppositories with other bowel treatments.

Table of Contents

Trial overview

The provided trial data includes one study of Glycerol in patients with bowel dysfunction after rectal cancer surgery.[1] The study title says it looked at treatment of bowel dysfunction after surgery for rectal cancer using transanal irrigation or laxatives.[1]

This was an interventional study, which means the researchers gave a treatment and then measured the effect.[1] The study status was completed.[1]

Who participated

The trial studied people with Low Anterior Resection Syndrome, a bowel problem that can happen after rectal cancer surgery.[1] The brief summary says the study involved patients who had unsatisfactory improvement of bowel function and quality of life with Glycerol suppositories, or who were being compared against another bowel treatment.[1]

The enrollment was 114 participants.[1] The study used a low-intervention design, which means the treatment approach was intended to be closer to routine care than a high-risk experimental study.[1]

What was studied

The intervention of interest was Glycerol “OBA” in suppository form, given by rectal use.[1] A suppository is a solid medicine placed in the rectum so it can act locally.[1]

The study compared Glycerol suppositories with transanal irrigation, which is a bowel washout method used to help empty the bowel.[1] The brief summary says the study aimed to see whether patients who did not improve enough with one approach would improve when switched to the other approach.[1]

Outcomes measured

The primary endpoint was the change in the main symptom score measured by the Measure Yourself Medical Outcome Profile (MYMOP).[1] This is a patient-reported score, meaning the patient reports how much the symptoms have changed.[1]

The brief summary also says the study looked at bowel function and quality of life.[1] Quality of life means how well a person feels and manages daily life.[1]

Trial status and size

The study is listed as completed, so the trial has already finished collecting its main data.[1] It included 114 people, which gives a moderate-sized group for this kind of focused bowel treatment study.[1]

The source data does not provide a formal drug-development phase such as Phase 1, Phase 2, or Phase 3 for this Glycerol trial.[1] Instead, it is described as a low-intervention study.[1]

What the results are meant to show

This trial was designed to find out whether Glycerol suppositories can help improve the symptoms that matter most to patients after rectal cancer surgery.[1] It also aimed to see whether another bowel treatment, transanal irrigation, might work better for some patients.[1]

In simple terms, the study asks which treatment gives better relief of bowel problems and better daily comfort for people living with Low Anterior Resection Syndrome.[1]

Trial IDPhaseCondition studiedStatusEnrollment
2024-519492-25-01Low InterventionLow Anterior Resection SyndromeCompleted114

FAQ

  • What is being studied in the Glycerol trials? The trials study Glycerol suppositories for bowel dysfunction after surgery for rectal cancer. They look at whether symptoms and quality of life improve with this treatment.
  • Who can take part in these trials? The study includes people with Low Anterior Resection Syndrome, which is bowel dysfunction after rectal cancer surgery. Participants had not improved enough with their current bowel treatment.
  • What phase is the Glycerol trial? The trial is listed as Low Intervention. This means it is a clinical study with a low-risk treatment approach rather than a drug development phase like Phase 1 or Phase 2.
  • What does the trial compare Glycerol with? The study compares Glycerol suppositories with transanal irrigation, which is a bowel washout method. It looks at which approach works better for symptoms and quality of life.
  • What is the main result the trial measures? The main result is the change in the main symptom score measured by MYMOP. This score shows how much the patient’s most important symptoms have changed.

Ongoing Clinical Trials on Glycerol

  • Study on the Effect of a New Moisturiser with Paraffin and Liquid Paraffin on Preventing Eczema Relapse in Children

    Not recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    Germany Sweden

Glossary

  • Low Anterior Resection Syndrome: A group of bowel problems that can happen after surgery for rectal cancer. It can include urgent bowel movements, frequent stools, and incomplete emptying.
  • Rectal cancer: Cancer that starts in the rectum, which is the last part of the large bowel.
  • Suppository: A solid medicine that is placed into the rectum, where it dissolves and acts locally.
  • Rectal use: A treatment given through the rectum.
  • Interventional study: A clinical trial in which researchers give a treatment and measure its effects.
  • Low Intervention: A study with a treatment approach considered low risk and closer to usual care.
  • Quality of life: How well a person feels and functions in daily life, including comfort, independence, and well-being.
  • MYMOP score: A patient-reported score called Measure Yourself Medical Outcome Profile. It tracks symptoms that matter most to the patient.
  • Symptom score: A number that shows how severe a symptom is.
  • Transanal irrigation: A bowel treatment that uses water through the anus to help empty the bowel.

References

  1. https://clinicaltrials.gov/study/2024-519492-25-01