United Kingdom – European Clinical Trials Information Network

Skåne University Hospital

Thu, 30 Apr 2026 09:20:57 +0000

Study of Atropine Sulfate eye drops (0.

Wed, 29 Apr 2026 15:01:51 +0000

This study focuses on treating myopia, also known as nearsightedness, in children. The condition occurs when distant objects appear blurry while close objects remain clear. The research evaluates a new eye drop solution called OT-101 containing atropine sulfate at a concentration of 0.01%.

The purpose of this study is to determine how well these eye drops work in slowing down the progression of myopia in children over a three-year treatment period. The study will compare the effectiveness of OT-101 eye drops against a placebo solution that looks the same but contains no active medication.

During the study, participants will receive either the OT-101 eye drops or placebo drops. The drops will be administered through ophthalmic use (placed directly in the eyes). The treatment will continue for three years, with regular check-ups to monitor changes in vision. The study will measure how the eye drops affect the progression of nearsightedness using specialized eye examinations.

Study of drug combination therapy for high-risk medulloblastoma in patients over 3 years of age: carboplatin, cisplatin, cyclophosphamide, lomustine, temozolomide, thiotepa, vincristine

Wed, 29 Apr 2026 14:58:10 +0000

This clinical trial focuses on treating high-risk medulloblastoma, which is a type of brain tumor. The study specifically targets patients who have either sonic hedgehog (SHH) subgroup or non-SHH/non-WNT (Groups 3 and 4) medulloblastoma with additional high-risk features. The treatment involves multiple medications including carboplatin, cisplatin, cyclophosphamide, lomustine, temozolomide, thiotepa, and vincristine sulfate.

The purpose of this study is to determine if treatment outcomes can be improved by using either specialized radiation therapy called hyperfractionated-accelerated radiotherapy or high-dose therapy with thiotepa, compared to standard radiation therapy. The study will also evaluate the effectiveness of different maintenance chemotherapy treatments.

The treatment plan combines various methods of drug administration, with some medications given through a vein (intravenous route) and others taken by mouth (oral route). The medications will be given according to specific schedules and doses determined by the study protocol. The study will track how well patients respond to treatment by measuring how long they remain free of disease progression and their overall survival.