Clinical trials located in

Schwerin

Schwerin city is located in Germany. Currently, 9 clinical trials are being conducted in this city.

Schwerin, the capital of Mecklenburg-Vorpommern, Germany, is renowned for its picturesque Schwerin Castle, situated on an island in the Schwerin Lake. This fairy-tale castle, now a museum, once served as the residence of dukes and grand dukes. The city’s history dates back over a thousand years, blending rich cultural heritage with natural beauty. Schwerin also boasts impressive architecture, like the Schwerin Cathedral, and hosts the Mecklenburg State Theatre. Its eleven lakes and lush greenery have earned it the nickname “The City of Seven Lakes and Forests.”

  • CT-EU-00116695

    Study on combining two drugs – Fianlimab and Cemiplimab in patients with previously untreated melanoma

    This study examines two drugs, fianlimab and cemiplimab, given together for the treatment of melanoma. The main goal is to see how effective this drug combination is in treating melanoma compared with pembrolizumab, which is already approved for the treatment of melanoma in adults. The study will also look at whether there are any differences in the effects of these experimental drugs in adolescents and adults.

    Scientists also want to learn about other key issues: what side effects may occur from taking these experimental drugs, how much of the drugs enter the bloodstream over time, and whether the body produces antibodies to the drugs that could make them less effective or cause side effects. They will also check whether taking medications improves patients’ quality of life. Fianlimab and cemiplimab will be administered by intravenous infusion, and pembrolizumab will be administered by intravenous infusion.

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  • Dose-finding study on Daridorexant for pediatric insomnia

    This study aims to figure out the right amount of daridorexant to give to children aged 10 to less than 18 who struggle with sleep. Researchers will be testing various doses of the medication to see how well it works and whether it’s safe for these kids. The goal is to find the most effective and suitable dose that can help improve their sleep without causing any harm.

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  • Comparison of different treatments for follicular lymphoma

    This study involves comparing two treatments for a condition known as follicular or marginal zone lymphoma, both of which are types of cancer affecting lymph cells. The first treatment combines zanubrutinib with an antibody called Anti-CD20, while the second treatment involves lenalidomide and rituximab. These treatments are intended for patients who have not responded or have stopped responding to conventional treatment. One of the primary objectives of the study is to determine which treatment is more effective in preventing the cancer from progressing, referred to as progression-free survival. Additionally, the study aims to assess the impact of these treatments on the patients’ quality of life, evaluating various aspects through questionnaires related to physical and emotional well-being, symptoms, and the ability to perform normal activities.

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  • Study on dazostinag & pembrolizumab for advanced solid tumors

    The purpose of this study is to test a new drug called dazostinag. A study is being conducted to see whether this drug is helpful in adults with advanced forms of solid cancer. Some people are given dazostinag alone, while others are given it with another medicine called pembrolizumab. Scientists’ focus here is on finding out whether these drugs cause any side effects, and finding out what the maximum dose is that people can take without serious side effects. The study consists of two parts, including a dose escalation phase and a dose escalation phase. In the first part, the dose of dazostinag will be gradually increased, given alone or in combination with pembrolizumab. In the second part, Dazostinag will be tested with pembrolizumab and other anticancer drugs. This section will focus on patients with specific cancers that are difficult to remove or have spread to other parts of the body.

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  • Comparing atogepant and topiramate for migraine prevention

    In this study, a comparison is being made between two different medicines aimed at preventing migraines in adults. Migraines manifest as severe headaches on one side of the head, accompanied by symptoms such as nausea, throbbing pain, or sensitivity to light and sound. The two medicines under comparison are named atogepant and topiramate. Atogepant is currently employed for migraine prevention in individuals experiencing migraines from 0 to 14 days per month, and the study seeks to evaluate its potential broader application. Topiramate is already widely utilized for migraine prevention. Participants in this study will be divided into two groups: one group will be administered atogepant, while the other will receive topiramate for a duration of 24 weeks. Following this period, those eligible to continue will all receive atogepant for an additional 52 weeks. The study will assess their progress and monitor any potential side effects.

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  • Understanding Elinzanetant’s role in Menopause-related Sleep Issues

    The aim of this study is to investigate the use of a new drug called Elinzanetant for menopausal women who struggle with sleep problems. Menopause often causes sleep problems, such as waking up multiple times during the night, which can make life difficult. It may block proteins that cause sleep problems. The study will investigate whether Elinzanetant improves sleep compared with placebo. Researchers will look at how much time women spend awake after falling asleep at night and their total sleep time after 4 and 12 weeks of treatment. Women in the study will receive Elinzanetant or placebo for 12 weeks. The study will last approximately 22 weeks and includes check-ups including blood and urine tests, physical examinations, sleep tests and home recording of sleep quality and hot flashes. Any health problems that arise during the study will be recorded, whether they are related to the study drugs or not.

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  • Study of new drugs in acute lymphoblastic leukemia

    This clinical trial focuses on improving treatment strategies for acute lymphoblastic leukemia (ALL) in a diverse age group, from infants to young adults up to 45 years old. The study combines standard treatments with new drugs, for example, Inotuzumab Ozogamicin and Blinatumomab. The trial aims to tailor treatment to individual patient needs and reduce toxicity while maintaining treatment quality. By carefully monitoring event- and disease-free survival rates, as well as minimal residual disease responses, the trial aims to improve the standard of care for ALL and improve both survival outcomes and patient quality of life.

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  • Exploring sacituzumab govitecan for HER2-negative breast cancer care

    This study is evaluating a new treatment for patients with a certain type of breast cancer (HER2-negative) who have not had a complete response to initial chemotherapy. Participants are randomly assigned to receive the investigational drug sacituzumab govitecan or a treatment of their physician’s choice, which may be another type of chemotherapy with capecitabinalub, carboplatin or cisplatin. The study is designed to compare the effectiveness of these approaches in preventing cancer recurrence. Patients may also receive hormone therapy if needed. Patients’ safety and response to treatment are being closely monitored throughout the study.

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  • Long-term effects and safety of the new drug for narcolepsy

    This study focuses on TAK-861, a drug developed to treat narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). The research aims to evaluate TAK-861’s safety using 160 volunteers who participated in previous narcolepsy studies. The volunteers will be divided into groups and given different doses of TAK-861, depending on their original dose in the parent study. The drug’s effectiveness in alleviating Narcolepsy symptoms such as excessive daytime sleepiness (EDS) and cataplexy episodes will also be observed. This study is intended to last up to 108 weeks with regular visits to the clinic for check-ups. At the end of the study, volunteers will receive a follow-up assessment four weeks after their last dose. While this exploration into the medicine’s long-term effects serves as a new step towards making advancements in narcolepsy treatment.

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