Clinical trials located in

San Giovanni Rotondo

San Giovanni Rotondo city is located in Italy. Currently, 17 clinical trials are being conducted in this city.

San Giovanni Rotondo, located in Italy’s Puglia region, is renowned for its deep religious heritage. This city is famously associated with Saint Padre Pio, a revered figure who lived and worked there. The Sanctuary of Saint Pio, attracting pilgrims worldwide, stands as a testament to his legacy. Beyond its spiritual significance, San Giovanni Rotondo is enveloped by the picturesque Gargano National Park, showcasing the area’s natural beauty. The city also boasts a rich architectural landscape, with the Padre Pio Pilgrimage Church, designed by renowned architect Renzo Piano, highlighting modern religious architecture.

  • CT-EU-00116695

    Study on combining two drugs – Fianlimab and Cemiplimab in patients with previously untreated melanoma

    This study examines two drugs, fianlimab and cemiplimab, given together for the treatment of melanoma. The main goal is to see how effective this drug combination is in treating melanoma compared with pembrolizumab, which is already approved for the treatment of melanoma in adults. The study will also look at whether there are any differences in the effects of these experimental drugs in adolescents and adults.

    Scientists also want to learn about other key issues: what side effects may occur from taking these experimental drugs, how much of the drugs enter the bloodstream over time, and whether the body produces antibodies to the drugs that could make them less effective or cause side effects. They will also check whether taking medications improves patients’ quality of life. Fianlimab and cemiplimab will be administered by intravenous infusion, and pembrolizumab will be administered by intravenous infusion.

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  • Iptacopan as a new hope for the treatment of paroxysmal nocturnal hemoglobinuria

    In this phase 3 trial, iptacopan’s efficacy and safety are assessed in adults with Paroxysmal Nocturnal Hemoglobinuria (PNH) who switch from standard anti-C5 treatments to iptacopan. The study, involving multiple centers, consists of an initial 8-week screening and a subsequent 24-week treatment phase with iptacopan. The primary focus is to determine if iptacopan can effectively manage PNH while maintaining patient safety. Participants showing benefits from iptacopan after the treatment period have the opportunity to continue in a roll-over extension study, allowing further observation of iptacopan’s long-term impacts.

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  • Study on new combination therapy for aggressive lymphoma

    This study is about a less common but severe form of cancer known as Diffuse Large B-Cell Lymphoma (DLBCL). It is testing if a new medication called epcoritamab, given with a mix of other commonly used cancer medicines, can help control the disease better. These other medicines include rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone, which are often collectively referred to as R-CHOP. The study includes about 900 adults from around the world who have recently been diagnosed with this type of lymphoma. They will be split into two groups. One group will get epcoritamab with R-CHOP and then continue with epcoritamab. The other group will get R-CHOP followed by rituximab. Doctors will carefully watch for changes in the disease and for any side effects. There will be many checks on health, including medical exams, blood tests, questionnaires, and monitoring of any side effects.

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  • Examining new drug impact on nonalcoholic fatty liver disease

    This study is evaluating GSK4532990 in adults with advanced non-alcoholic steatohepatitis (NASH). This is a Phase 2b trial comparing GSK4532990 with placebo, focusing on liver fibrosis and inflammation relief. The study will include high-dose, low-dose and placebo groups and will include 246 participants. Primary outcomes are improvement in histologic fibrosis and resolution of NASH at 52 weeks. Secondary outcomes include changes in liver and fat markers.

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  • Testing new medication for safety and effect on Huntington’s disease

    This clinical trial evaluates the safety and efficacy of PTC518, a medication for Huntington’s Disease. The study involves adults with genetically confirmed Huntington’s Disease, receiving either PTC518 or a placebo. Over 12 months, the trial will monitor changes in symptoms and any adverse effects. The goal is to understand if PTC518 can safely and effectively manage Huntington’s Disease symptoms, potentially offering a new treatment option for those affected by this neurodegenerative disorder.

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  • Comparing treatments in multiple myeloma: talquetamab in combination with other medication

    This study aims to explore the combined effects of talquetamab, daratumumab, pomalidomide, and dexamethasone for treating relapsed or refractory multiple myeloma. One group of patients will receive talquetamab subcutaneous in combination with daratumumab and pomalidomide. The second group will receive talquetamab subcutaneous in combination with daratumumab. The patients of the third group will be treated with daratumumab subcutaneous in combination with pomalidomide and dexamethasone. The research is divided into three phases: screening, treatment, and post-treatment follow-up. The study will assess efficacy, safety, and monitoring various health indicators at specific time points. The results of this combination therapy will be compared to choose the safest and the most effective treatment. The overall duration of the study is expected to be up to 6 years and 6 months.

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  • Testing ravulizumab for transplant-related blood complications

    The study is examining a drug called ravulizumab used in adults and teenagers with a blood vessel disease called thrombotic microangiopathy (TMA) after a bone marrow transplant. Sometimes, new cells growing after a bone marrow transplant can cause problems in the blood vessels leading to TMA. So this study will investigate whether ravulizumab can help in this situation. In the first stage, each participant will receive the drug to determine the best dose. In the second phase, some will receive ravulizumab and best supportive care, while others will receive placebo and best supportive care. After 26 weeks of treatment, doctors will continue to monitor and record the patients’ health for another 26 weeks. Special blood tests will be done to check if the medicine is working.

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  • Study on a new combination therapy for active ulcerative colitis

    This study aims to assess the effectiveness and safety of new combination therapy with JNJ-78934804 (Guselkumab/Golimumab) in comparison to guselkumab and golimumab administred alone for individuals with moderately to severely active ulcerative colitis. Participants who have shown inadequate response, loss of response, or intolerance to approved advanced therapies will be included. The trial includes various treatment groups: placebo, Guselkumab, Golimumab, and different doses of JNJ-78934804. All participants meeting inadequate response criteria will be escalated to an active treatment. The study will last for 48 weeks and the progress will be tracked over this period. The primary focus is to evaluate the efficacy and safety of the different doses of new therapy in managing ulcerative colitis over the course of the study.

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  • Exploring the effect and safety of a new treatment for Severe Ulcerative Colitis

    This clinical trial aims to explore the potential of NX-13, a new oral medication, in providing relief to adults suffering from moderate to severe ulcerative colitis, a chronic condition that causes inflammation and ulcers in the digestive tract, leading to discomfort and other debilitating symptoms. The study is designed to test two different doses of NX-13, 250mg and 750mg, comparing them with a placebo to determine the medication’s effectiveness in managing the symptoms of this condition.

    Participants in the study will be carefully monitored to assess how well NX-13 controls the inflammation and symptoms associated with ulcerative colitis, and to ensure the safety and tolerability of the medication. The study also aims to understand the long-term impacts of the medication, with an extension period included to gather more comprehensive data on its sustained effects.

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  • Comparison of different treatments for follicular lymphoma

    This study involves comparing two treatments for a condition known as follicular or marginal zone lymphoma, both of which are types of cancer affecting lymph cells. The first treatment combines zanubrutinib with an antibody called Anti-CD20, while the second treatment involves lenalidomide and rituximab. These treatments are intended for patients who have not responded or have stopped responding to conventional treatment. One of the primary objectives of the study is to determine which treatment is more effective in preventing the cancer from progressing, referred to as progression-free survival. Additionally, the study aims to assess the impact of these treatments on the patients’ quality of life, evaluating various aspects through questionnaires related to physical and emotional well-being, symptoms, and the ability to perform normal activities.

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  • Study on dazostinag & pembrolizumab for advanced solid tumors

    The purpose of this study is to test a new drug called dazostinag. A study is being conducted to see whether this drug is helpful in adults with advanced forms of solid cancer. Some people are given dazostinag alone, while others are given it with another medicine called pembrolizumab. Scientists’ focus here is on finding out whether these drugs cause any side effects, and finding out what the maximum dose is that people can take without serious side effects. The study consists of two parts, including a dose escalation phase and a dose escalation phase. In the first part, the dose of dazostinag will be gradually increased, given alone or in combination with pembrolizumab. In the second part, Dazostinag will be tested with pembrolizumab and other anticancer drugs. This section will focus on patients with specific cancers that are difficult to remove or have spread to other parts of the body.

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  • A study of lanifibranor treatment in adults with nonalcoholic fatty liver disease

    This study is a two-part trial looking at how well a drug called Lanifibranor works for adults suffering from liver diseases known as NASH and fibrosis stages F2 and F3. In the first part of the trial, the researchers will compare the effects of Lanifibranor with a placebo, which is a substance with no medical effect. The researchers will be looking at how much the drug can improve the health of the liver. The second part of the study will continue the use of Lanifibranor to see if there are any long-term safety issues. Apart from studying the drug’s effectiveness in resolving NASH and reducing live fibrosis, the trial will also be observing how it affects other aspects of liver health, diabetes, blood sugar and fat levels, liver stiffness and patients’ quality of life.

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  • A study on a new treatment for Hypophosphatasia

    This trial focuses is on evaluating the efficacy of a novel drug, ALXN1850, in assisting adolescents and adults diagnosed with Hypophosphatasia (HPP), a condition characterized by the deficiency of alkaline phosphatase enzyme. ALXN1850 aims to substitute this lacking enzyme and will be administered through subcutaneous injections. The primary objective is to assess the performance of the new drug in comparison to a placebo. The trial is conducted in a blinded manner, ensuring that participants remain unaware of whether they are receiving the actual drug or the placebo. The paramount goal is to ascertain the safety and effectiveness of the new treatment.

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  • Comparatively studying drug combinations for multiple myeloma treatment

    This study is testing different combinations of drugs used to treat a cancer called multiple myeloma. Patients will receive one of two sets of treatments. One set contains a medicine called belantamab mafodotin combined with two others, while the second set contains the same two medicines but with another third medicine called bortezomib. The main goal is to determine which of these combinations is more effective in patients with multiple myeloma, especially those for whom other treatments have failed. Researchers will measure how many participants see the disease go away, how long the disease is kept in check, and overall survival rates. In addition, they will use questionnaires to assess your quality of life and understand the range of symptoms or problems you may experience during the examination.

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  • Effectiveness of ivosidenib for advanced cholangiocarcinoma treatment

    This study is about taking a medicine called Ivosidenib to help adults that have been treated before for a serious type of liver cancer known as cholangiocarcinoma. The medicine is taken as a tablet once a day for 28 days, which is known as one cycle. The medicine is already approved for use in the US and Europe, but this study wants to understand better how it works and how it affects patients’ lives. There’ll be at least 6 visits to the doctor for anyone taking part, which include things like heart checks, physical exams, and tests on your blood and urine. After stopping treatment, you’ll have a follow-up visit every 6 months for up to 18 months. If at any point, Ivosidenib becomes available at your local pharmacy, you’ll stop the study and continue using it as a normal medicine. The researchers will keep checking in to see how you’re doing.

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  • Study of new drugs in acute lymphoblastic leukemia

    This clinical trial focuses on improving treatment strategies for acute lymphoblastic leukemia (ALL) in a diverse age group, from infants to young adults up to 45 years old. The study combines standard treatments with new drugs, for example, Inotuzumab Ozogamicin and Blinatumomab. The trial aims to tailor treatment to individual patient needs and reduce toxicity while maintaining treatment quality. By carefully monitoring event- and disease-free survival rates, as well as minimal residual disease responses, the trial aims to improve the standard of care for ALL and improve both survival outcomes and patient quality of life.

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  • Exploring sacituzumab govitecan for HER2-negative breast cancer care

    This study is evaluating a new treatment for patients with a certain type of breast cancer (HER2-negative) who have not had a complete response to initial chemotherapy. Participants are randomly assigned to receive the investigational drug sacituzumab govitecan or a treatment of their physician’s choice, which may be another type of chemotherapy with capecitabinalub, carboplatin or cisplatin. The study is designed to compare the effectiveness of these approaches in preventing cancer recurrence. Patients may also receive hormone therapy if needed. Patients’ safety and response to treatment are being closely monitored throughout the study.

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