Clinical trials located in

Oviedo

Oviedo city is located in Spain. Currently, 20 clinical trials are being conducted in this city.

Oviedo, the capital city of Asturias in Spain, is steeped in history and culture. Founded in the 8th century, it boasts a rich architectural heritage, including the UNESCO World Heritage Site of the Cathedral of San Salvador, known for its Holy Chamber housing significant Christian relics. The city is also famous for its pre-Romanesque buildings, such as San Julián de los Prados. Oviedo inspired the setting for Woody Allen’s film “Vicky Cristina Barcelona,” acknowledging its picturesque streets and vibrant cultural scene. The city is renowned for its Asturian cuisine, particularly fabada asturiana, and the traditional cider.

  • CT-EU-00117746

    Study of Pembrolizumab/Quavonlimab Combination vs Other Treatments for Colorectal Cancer

    This here clinical trial is aimin’ to take a good look at a new combination treatment called co-formulated pembrolizumab/quavonlimab for folks with stage IV colorectal cancer that’s got that microsatellite instability-high or mismatch repair deficient business goin’ on. The main goal is to see how well this new combo treatment works at shrinkin’ them tumors, compared to some other treatments out there.

    Now, the real important part is that the doctors’ll be keepin’ a close eye on how many folks get what they call an objective response, meanin’ their tumors either disappear completely or shrink down by at least 30%. They’ll be trackin’ this over a span of up to around 50 months to get a good picture of how effective this new treatment is.

    Safety’s always a top priority too, so the doctors’ll be watchin’ out for any side effects or issues that might crop up with this new combo treatment. It’s all about findin’ the best way to fight that cancer while keepin’ folks as comfortable as possible.

  • Study on combining two drugs – Fianlimab and Cemiplimab in patients with previously untreated melanoma

    This study examines two drugs, fianlimab and cemiplimab, given together for the treatment of melanoma. The main goal is to see how effective this drug combination is in treating melanoma compared with pembrolizumab, which is already approved for the treatment of melanoma in adults. The study will also look at whether there are any differences in the effects of these experimental drugs in adolescents and adults.

    Scientists also want to learn about other key issues: what side effects may occur from taking these experimental drugs, how much of the drugs enter the bloodstream over time, and whether the body produces antibodies to the drugs that could make them less effective or cause side effects. They will also check whether taking medications improves patients’ quality of life. Fianlimab and cemiplimab will be administered by intravenous infusion, and pembrolizumab will be administered by intravenous infusion.

    • placebo
    • Fianlimab
    • Cemiplimab
    • Pembrolizumab
  • Study on Ravulizumab’s effect on Immunoglobulin A Nephropathy

    The study is looking into the effectiveness of a medication called ravulizumab for adults who have a kidney condition known as Immunoglobulin A Nephropathy (IgAN). This condition can lead to kidney damage over time, and the study aims to find out if ravulizumab can help reduce the amount of protein lost in urine—a common problem in IgAN—and slow down the decrease in kidney function.

    In this study, about 450 participants who are at a high risk of their disease getting worse will be chosen. These participants must have been on stable treatment for their IgAN for at least three months before the study starts. They will then receive either ravulizumab or a placebo, which is a treatment with no active drug, through an IV infusion based on their weight. The main goal is to see if those who receive ravulizumab have a significant improvement in their condition compared to those who receive the placebo.

    The study will have two main checkpoints. The first one, at Week 34, will check how much protein is in the urine, and the second one, at Week 106, will assess how well the kidneys are filtering waste from the blood. Additionally, a smaller group of participants with more advanced kidney issues will receive ravulizumab to further explore its effects.

    After the study ends at Week 106, participants will have the option to continue receiving ravulizumab in a follow-up period to see how long-term treatment affects their condition. This study is a chance for people with IgAN to potentially slow down their disease progression and improve their quality of life.

    • placebo
    • Ravulizumab
  • Study of belzutifan for treating advanced cancers

    This clinical trial aim is to test out a new drug called belzutifan, also known as MK-6482 or WELIREG™. It’s a pill patient can take once a day, and the main goal is to see if it can shrink or get rid of tumors in folks with certain types of cancer.

    The cancers the researchers are looking at are pheochromocytoma and paraganglioma, which are tumors that start in the adrenal glands or nervous system. Pancreatic neuroendocrine tumors, tumors related to von Hippel-Lindau disease, advanced gastrointestinal stromal tumors, and other solid tumors with certain genetic changes that involve a protein called HIF-2α, there will be also tested.

    The big thing the researchers are  keeping an eye on is the objective response rate, which means how many folks see their tumors shrink or disappear completely while taking this drug. The researchers will be watching closely for any side effects too, of course, to make sure this new medicine is safe.

    • Belzutifan
  • Testing the effectiveness of new drugs in the treatment of age-related macular degeneration

    The study is investigating a potential breakthrough in treating age-related vision loss, specifically neovascular age-related macular degeneration (nAMD). It introduces a novel therapy, OPT-302, and pairs it with Aflibercept, comparing this combination’s effectiveness against the standard treatment. Participants undergo a series of thorough eye examinations and treatments to monitor the progression of their vision health. The research aims to offer a clearer understanding of how these treatments can better manage and possibly improve vision for individuals dealing with nAMD, contributing valuable knowledge to the field of eye health care.

    • aflibercept
    • OPT-302
  • Comparing a new treatment with standard care for advanced colorectal cancer

    This research study is for people suffering from a type of bowel cancer that has spread to other parts of the body, known as ‘metastatic colorectal cancer’. The purpose of the study is to compare a new combination of medications against the regular treatments that are already in use. Patients participating in the study will be placed into two groups: one group will receive the standard treatment, and the other group will try a new combination of drugs (tucatinib, trastuzumab, and 5-Fluorouracil, leucovorin,,oxaliplatin). This study will also help to understand the side effects, which are any unexpected symptoms or changes that can occur when taking these medications. Ultimately, the goal of this study is to help learn more about which treatment is more effective in delaying the progression of the disease and improving the patients’ quality of life.

    • levoleucovorin
    • leucovorin
    • Fluorouracil
    • Bevacizumab
    • Cetuximab
    • Tucatinib
    • Oxaliplatin
    • Trastuzumab
  • Advanced lung cancer treatment: comparing osimertinib with standard chemotherapy

    In this extended study, researchers are evaluating two treatment approaches for non-small cell lung cancer (NSCLC), focusing on patients who have experienced disease progression extracranially after initial treatment with osimertinib. The study aims to compare the efficacy and safety of chemotherapy combined with osimertinib versus chemotherapy combined with a placebo. Patients are randomly assigned to one of two groups. Group A receives osimertinib daily along with two chemotherapy drugs (cisplatin or carboplatin and pemetrexed) for four 21-day cycles. After these cycles, they continue taking osimertinib with maintenance pemetrexed. Group B follows a similar protocol but with a placebo instead of osimertinib. The study’s objective is to understand which treatment method better helps patients with this specific cancer profile, considering factors like genetic mutations and the presence of brain metastases. By observing the treatment’s impact on disease progression and patient safety, the researchers hope to gain insights that could improve NSCLC treatment strategies.

    • AZD9291 (Osimertinib)
    • Cisplatin
    • Carboplatin
    • Pemetrexed
  • Evaluating dostarlimab for treating stage III colon cancer

    This research is focused on the investigation of the effect of dostarlimab on patients with severe, untreated colon cancer (T4N0 or Stage III dMMR/MSI-H). The primary objective is to assess whether dostarlimab yields superior outcomes for the patients in comparison to standard treatments. Patient monitoring will be based on tumor response and the potential impact on their quality of life resulting from the drug or disease progression.

    • CAPEOX
    • Dostarlimab
    • FOLFOX
  • To study the efficacy and safety of Alpelisib and Fulvestrant in patients with advanced breast cancer after prior treatment

    The study is aimed at patients with advanced breast cancer, which is hormone-dependent (HR+) and HER2-negative, which means that cancer cells develop under the influence of hormones and at the same time do not have a large number of HER2 receptors. Patients must have a mutation in the PIK3CA gene and progressive cancer after previous therapy with CDK4/6 inhibitors and aromatase inhibitors.

    The study will use two drugs: Alpelisib, administered in the form of tablets, and Fulvestrant, administered as intramuscular injections. Both of these therapies will be compared with placebo in combination with fulvestrant. The aim of the study is to evaluate the effectiveness and safety of combined treatment with alpelisib and fulvestrant compared to placebo plus fulvestrant.

    • Alpelisib
    • Fulvestrant
  • Pralsetinib vs regular care in treating advanced lung cancer

    This study is looking at how effective a medication called Pralsetinib is in treating a type of lung cancer called RET Fusion-Positive, Metastatic Non-Small Cell Lung Cancer. This cancer type is difficult to treat and usually spreads to other parts of the body. The medicine will be compared to the usual treatments given for this type of cancer. Doctors want to see if Pralsetinib can slow down or stop the cancer progression and how long that lasts. Any side effects experienced by patients will be carefully monitored to understand the medication’s safety.

    • Pralsetinib
    • Gemcitabine
    • Pemetrexed
    • Cisplatin
    • Carboplatin
    • Pembrolizumab
    • nab-Paclitaxel
    • Paclitaxel
  • Testing ravulizumab for transplant-related blood complications

    The study is examining a drug called ravulizumab used in adults and teenagers with a blood vessel disease called thrombotic microangiopathy (TMA) after a bone marrow transplant. Sometimes, new cells growing after a bone marrow transplant can cause problems in the blood vessels leading to TMA. So this study will investigate whether ravulizumab can help in this situation. In the first stage, each participant will receive the drug to determine the best dose. In the second phase, some will receive ravulizumab and best supportive care, while others will receive placebo and best supportive care. After 26 weeks of treatment, doctors will continue to monitor and record the patients’ health for another 26 weeks. Special blood tests will be done to check if the medicine is working.

    • Ravulizumab
  • Testing navitoclax and ruxolitinib effective on myelofibrosis patients

    This study is trying to find out if the combination of two drugs called Navitoclax and Ruxolitinib can help people with a type of blood cancer called Myelofibrosis. Around 330 adults, who have myelofibrosis that hasn’t responded to previous treatments, will get either the new drug combination or the current best treatment for their disease. Doctors will measure whether the new combination is more effective by checking how much the size of participants’ spleens have changed during the study with scans, measuring fatigue levels and checking how well their bone marrow works.

    • Navitoclax
    • Ruxolitinib
  • Studying atenativ’s effectiveness in congenital antithrombin deficiency

    This study is designed to evaluate a new medication named Atenativ, intended for individuals with congenital antithrombin deficiency, a condition where the blood tends to form clots too easily. The study aims to assess the potential utility of Atenativ, particularly during situations such as surgery or childbirth, where there is an increased risk of blood clotting. The primary focus of the study is to determine the frequency of blood clot occurrences in individuals using Atenativ. Additionally, the research will investigate the pharmacokinetics of Atenativ, including its duration of presence in the body, elimination rate, and its impact on blood and clotting tests. Throughout the study, any side effects or adverse reactions experienced by individuals taking the medication will be carefully documented.

    • Atenativ
  • Comparison of different treatments for follicular lymphoma

    This study involves comparing two treatments for a condition known as follicular or marginal zone lymphoma, both of which are types of cancer affecting lymph cells. The first treatment combines zanubrutinib with an antibody called Anti-CD20, while the second treatment involves lenalidomide and rituximab. These treatments are intended for patients who have not responded or have stopped responding to conventional treatment. One of the primary objectives of the study is to determine which treatment is more effective in preventing the cancer from progressing, referred to as progression-free survival. Additionally, the study aims to assess the impact of these treatments on the patients’ quality of life, evaluating various aspects through questionnaires related to physical and emotional well-being, symptoms, and the ability to perform normal activities.

    • Zanubrutinib
    • Obinutuzumab
    • Lenalidomide
    • Rituximab
  • Study on dazostinag & pembrolizumab for advanced solid tumors

    The purpose of this study is to test a new drug called dazostinag. A study is being conducted to see whether this drug is helpful in adults with advanced forms of solid cancer. Some people are given dazostinag alone, while others are given it with another medicine called pembrolizumab. Scientists’ focus here is on finding out whether these drugs cause any side effects, and finding out what the maximum dose is that people can take without serious side effects. The study consists of two parts, including a dose escalation phase and a dose escalation phase. In the first part, the dose of dazostinag will be gradually increased, given alone or in combination with pembrolizumab. In the second part, Dazostinag will be tested with pembrolizumab and other anticancer drugs. This section will focus on patients with specific cancers that are difficult to remove or have spread to other parts of the body.

    • Dazostinag
    • Platinum
    • Pembrolizumab
    • 5-Fluorouracil
  • Exploring safe treatment options for Multiple Sclerosis

    This study is investigating the effects of Ofatumumab and Siponimod in comparison to a medication called Fingolimod in young patients with Multiple Sclerosis. The study comprises two parts: the Core Part, which spans two years, and the Extension Part, which can last up to five years. In the Core Part, participants are assigned one of the three medications to compare their respective effects. Qualified participants from the Core Part have the option to continue their treatment in the Extension Part. Progress is monitored by assessing the number of disease exacerbations per year, observing changes in scans that detect alterations related to the disease, and conducting blood tests. These blood tests are instrumental in measuring the levels of the medications in the body and ensuring that they do not have adverse effects.

    • Siponimod
    • Ofatumumab
    • Fingolimod
  • Testing Treprostinil Palmitil inhalation powder for pulmonary arterial pressure

    This trial is about a new drug called Treprostinil Palmitil Inhalation Powder (TPIP). TPIP is tested on people who have a condition where the blood pressure in the lungs is too high. This condition is called Pulmonary Arterial Hypertension. The objective of this study is to ascertain the effectiveness and safety of TPIP, and to examine its pharmacokinetics, i.e., how it moves within the body. The trial is set up in such a way that some people will get TPIP, while others receive a placebo. The primary focus is on determining whether TPIP can effectively reduce resistance to blood flow within the lungs, constituting a key aspect of the study’s goals.

    • Treprostinil Palmitil
  • Study on the safety and effectiveness of luspatercept in myelodysplastic syndromes patients

    The aim of this study is to test a drug called Luspatercept in people with lower-risk myelodysplastic syndrome (MDS) characterized by ring sideroblasts (MDS-RS), a condition in which the body does not produce enough healthy blood cells. The main aim of the study is to see if Luspatercept can help patients who require regular blood transfusions due to anemia. The study will also look at how long it takes for the medicine to work, how long it lasts, and changes in the need for blood transfusions and levels of hemoglobin (an important protein in red blood cells). The study will also measure changes in certain substances in the blood and the progression of their MDS. Finally, the study will use questionnaires to understand how patients’ lives and physical abilities have changed over time.

    • Luspatercept
  • Comparison of two drugs in the treatment of venous thromboembolism

    The study compares abelacimab and dalteparin in treating blood clot issues in patients with gastrointestinal or genitourinary cancers. It’s open to adults, focusing on those without plans for curative surgery. Abelacimab is given monthly, and dalteparin daily, over six months. It assesses clot recurrence, bleeding risks, and treatment continuation. The goal is to find safer, effective blood clot treatments for cancer patients, improving their care and outcomes.

    • Abelacimab
    • Dalteparin
  • Testing drug combinations in recurring multiple myeloma

    This is a type of research study where the researchers compare two different treatments for multiple myeloma, a type of cancer in your blood. In the study, people will be placed into different groups and receive either a combination of iberdomide, daratumumab, and dexamethasone, or another combination of daratumumab, bortezomib, and dexamethasone. The researchers want to check how well the cancer responds to these treatments and see which one works better.

    • Iberdomide
    • Dexamethasone
    • Bortezomib
    • Daratumumab

See more clinical trials in other cities in Spain:

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