Clinical trials located in

Nîmes

Nîmes city is located in France. Currently, 15 clinical trials are being conducted in this city.

Nîmes, located in southern France, is a city steeped in ancient history, famously known for its well-preserved Roman monuments. Among its most iconic landmarks is the Arena of Nîmes, an amphitheater dating back to around 70 AD, which could hold 24,000 spectators in its heyday. Another significant Roman site is the Maison Carrée, one of the best-preserved Roman temple façades in the world. Nîmes is also the birthplace of denim fabric, originally called “serge de Nîmes,” highlighting its historical significance in textile production.

  • CT-EU-00117988

    Baricitinib study in children with juvenile idiopathic arthritis

    This clinical trial is designed to test whether Baricitinib is safe and effective in the treatment of systemic juvenile idiopathic arthritis in children aged 1 to 18 years. Participants will be assigned to one of two groups. In the first group, some participants will receive Baricitinib and others Tocilizumab as the reference drug. In the second group, all participants will receive Baricitinib.

    The primary objective of the study is to evaluate the percentage of participants who experience at least a 30% improvement in disease symptoms after 12 weeks of treatment according to the modified American College of Rheumatology Pediatric Response Criteria (PediACR30). Baricitinib is administered orally and Tocilizumab is administered by subcutaneous injection.

    • Tocilizumab
    • baricitinib
  • Study of the new oral drug LY3871801 for rheumatoid arthritis

    The aim of this study is to test a new drug called LY3871801 for people suffering from moderate to severe rheumatoid arthritis. The main goal is to see if this new drug can help reduce disease activity and improve symptoms better than a placebo. In the first part of the study, doctors will check how much the Disease Activity Score changes after 12 weeks of taking LY3871801 or a placebo. Then, in the second part, they will look at what percentage of patients experience significant improvement, defined as achieving an ACR50 response, which means reducing symptoms of rheumatoid arthritis by 50% or more. Both the real drug and the placebo will be taken by mouth.

    • placebo
    • LY3871801
  • Exploring a new treatment combination for rheumatoid arthritis: baricitinib plus anti-TNF

    This clinical trial is focused on finding a more effective treatment for people with Rheumatoid Arthritis (RA) who haven’t responded well to previous therapies. The study is comparing two different approaches: one group will receive a combination of baricitinib treatment and an anti-TNF therapy (adalimumab), while the other group will receive baricitinib along with a placebo. The main goal is to see which group shows a greater improvement in their RA symptoms, specifically looking for a 50% improvement in symptoms, known as an ACR 50 response, after 24 weeks from the start of the treatment.

    Baricitinib is a medication that targets certain pathways in the body’s immune system to reduce inflammation and pain in RA. Anti-TNF therapy, like adalimumab, works by blocking the action of a protein in the body that causes inflammation. By combining these two treatments, researchers hope to see a more significant improvement in RA symptoms than with baricitinib alone.

    The trial is important because it aims to provide a new option for patients with RA who have not found relief with current treatments. It’s designed to test the safety and effectiveness of using these two different types of medications together.

    • placebo
    • Adalimumab
    • Baricitinib
  • Comparison of zibotentan/dapagliflozin with dapagliflozin alone in the treatment of chronic kidney disease with high proteinuria

    The study aims to understand how to better treat people with chronic kidney disease (CKD) and high proteinuria. This study is in its third phase and involves multiple centers where participants will be closely monitored. The main goal is to compare the effectiveness, safety, and how well participants tolerate a combination treatment of zibotentan/dapagliflozin versus dapagliflozin alone.

    During this study, participants will be randomly assigned to one of two groups. One group will receive the combination of zibotentan and dapagliflozin, while the other group will receive only dapagliflozin. Both treatments aim to slow down the decline in kidney function, which is a major concern for people with CKD and high proteinuria. The key measure of success for this study is the change in eGFR from baseline, which is a test used to check how well the kidneys are working, specifically by measuring the estimated glomerular filtration rate (eGFR). This will be assessed at the 24-month mark of the study.

    This research is crucial because it could lead to better treatment options for those suffering from CKD and high proteinuria, potentially improving their quality of life and health outcomes.

    • Zibotentan/Dapagliflozin
    • Dapagliflozin
  • Study of lacutamab in T-cell lymphoma

    This trial involves a medication called lacutamab, which will be given to patients who have a type of blood cancer known as peripheral T-cell lymphoma, and their disease has either come back after previous treatment or didn’t respond at all. Some patients in the study will receive lacutamab in combination with a common chemotherapy drugs gemcitabine and oxaliplatine, while others will get only gemcitabine and oxaliplatine. A key aim of this study is to find out if lacutamab is both safe and effective. The study is designed not to compare the two treatments directly, but to check our assumptions for deciding the number of people for the trial. The number of participants getting lacutamab is bigger.

    • Lacutamab
    • Oxaliplatine
    • Gemcitabine
  • Testing the safety and effectiveness of alpelisib for MCAP syndrome

    This study is testing a medication called Alpelisib in people with a rare condition called Megalencephaly-Capillary Malformation Polymicrogyria Syndrome (MCAP). The study will be split into two sections. The first is a 6-month trial where some people will be given Alpelisib and others a placebo (a harmless, inactive substance), but no one will know which group they are in. This is to precisely measure the medication’s effects. After this, all qualifying participants will receive Alpelisib for the remaining 18 months. Participants’ progress will be monitored regularly, and the effects of the medicine will be assessed primarily using a scale that measures improvement in everyday skills and quality of life. The study also examines the medicine’s impact on brain growth and function using MRI scans and other tests.

    • Alpelisib
  • Studying ustekinumab treatment for Crohn’s perianal fistula

    This is a medical study being conducted to examine how effective a certain medication, called Ustekinumab, can be for people suffering from Crohn’s disease, specifically a subset called perianal Crohn’s. A group of people suffering from moderate to severe forms of this disease will be randomly assigned to receive either the actual medication or a placebo. Their symptoms will then be tracked for a period of 48 weeks to see if the medication helps lessen their symptoms. The end goal is to see whether the drug is useful in stopping all abnormal openings (fistulas) from draining. The study also aims to ensure that the drug doesn’t cause any buildup of more than 2 cm.

    • Ustekinumab
  • Testing ADT with or without darolutamide in prostate cancer patients

    This study is about testing how well two different kinds of prostate cancer treatment work. One treatment is called ADT (Androgen deprivation therapy) and the other is called darolutamide. In total, around 300 men who have just been diagnosed with prostate cancer will take part. The people in the study will be split into two groups. Half of the people will have the ADT treatment with placebo, while the other half will have both the ADT and darolutamide treatment. This will help the researchers understand whether adding darolutamide makes the ADT treatment work better. To check how well the treatment is working, the researchers will be using different methods.

    • Androgen deprivation therapy
    • Darolutamide
  • Study on a new combination therapy for active ulcerative colitis

    This study aims to assess the effectiveness and safety of new combination therapy with JNJ-78934804 (Guselkumab/Golimumab) in comparison to guselkumab and golimumab administred alone for individuals with moderately to severely active ulcerative colitis. Participants who have shown inadequate response, loss of response, or intolerance to approved advanced therapies will be included. The trial includes various treatment groups: placebo, Guselkumab, Golimumab, and different doses of JNJ-78934804. All participants meeting inadequate response criteria will be escalated to an active treatment. The study will last for 48 weeks and the progress will be tracked over this period. The primary focus is to evaluate the efficacy and safety of the different doses of new therapy in managing ulcerative colitis over the course of the study.

    • JNJ-78934804/guselkumab + golimumab
    • Golimumab
    • Guselkumab
  • Comparison of different treatments for follicular lymphoma

    This study involves comparing two treatments for a condition known as follicular or marginal zone lymphoma, both of which are types of cancer affecting lymph cells. The first treatment combines zanubrutinib with an antibody called Anti-CD20, while the second treatment involves lenalidomide and rituximab. These treatments are intended for patients who have not responded or have stopped responding to conventional treatment. One of the primary objectives of the study is to determine which treatment is more effective in preventing the cancer from progressing, referred to as progression-free survival. Additionally, the study aims to assess the impact of these treatments on the patients’ quality of life, evaluating various aspects through questionnaires related to physical and emotional well-being, symptoms, and the ability to perform normal activities.

    • Zanubrutinib
    • Obinutuzumab
    • Lenalidomide
    • Rituximab
  • Study on dazostinag & pembrolizumab for advanced solid tumors

    The purpose of this study is to test a new drug called dazostinag. A study is being conducted to see whether this drug is helpful in adults with advanced forms of solid cancer. Some people are given dazostinag alone, while others are given it with another medicine called pembrolizumab. Scientists’ focus here is on finding out whether these drugs cause any side effects, and finding out what the maximum dose is that people can take without serious side effects. The study consists of two parts, including a dose escalation phase and a dose escalation phase. In the first part, the dose of dazostinag will be gradually increased, given alone or in combination with pembrolizumab. In the second part, Dazostinag will be tested with pembrolizumab and other anticancer drugs. This section will focus on patients with specific cancers that are difficult to remove or have spread to other parts of the body.

    • Dazostinag
    • Platinum
    • Pembrolizumab
    • 5-Fluorouracil
  • Study on single drug therapy in heart patients after stent implantation

    This study is for patients with a heart condition called atrial fibrillation who will be getting a type of heart stent, or tiny tube put into a blood vessel, called a Supraflex Stent. After stenting, patients usually have to take many medications to prevent blood clots. However, these medications can also make people bleed more easily, which is not good. The usual strategy is to give patients three of these medications for a week up to a month, then two for up to 6–12 months, and then just one for the long term. In this study, the investigators will try out a different strategy where only one medication is used at a time. For the first month after stenting, an antiplatelet, a medication to stop blood clotting will be given, then after, an anticoagulant, another type of medication to prevent blood clots will be used. The aim is to see if this approach leads to fewer bleeding problems, while still protecting against blood clots.

    • P2Y12 inhibitor
    • Aspirin
    • DOAC-Direct oral anticoagulant
  • New drug trial in rapidly progressive glomerulonephritis

    This clinical trial investigates a new medication for patients with a specific autoimmune disease (ANCA-associated vasculitis or AAV) that mainly affects small blood vessels, often in the kidneys. The trial aims to determine the safety and effectiveness of the new drug (ALE.F02) in preserving kidney function when added to standard treatments. It involves 60 participants who will receive either the new drug or a placebo, alongside standard therapy, over a 24-week period. Participants will undergo various assessments, including physical examinations, blood and urine tests, and chest scans, to monitor their health and the drug’s impact. The study’s primary goal is to evaluate the drug’s tolerability and ability to protect kidney function, compared to a placebo.

    • ALE.F02 (lixudebart)
    • GlucoCorticoid
    • Cyclophosphamid
    • Immunosuppressive Agents
    • Rituximab
  • Study of new drugs in acute lymphoblastic leukemia

    This clinical trial focuses on improving treatment strategies for acute lymphoblastic leukemia (ALL) in a diverse age group, from infants to young adults up to 45 years old. The study combines standard treatments with new drugs, for example, Inotuzumab Ozogamicin and Blinatumomab. The trial aims to tailor treatment to individual patient needs and reduce toxicity while maintaining treatment quality. By carefully monitoring event- and disease-free survival rates, as well as minimal residual disease responses, the trial aims to improve the standard of care for ALL and improve both survival outcomes and patient quality of life.

    • Inotuzumab Ozogamicin
    • 6-tioguanine
    • Blinatumomab
    • Imatinib
    • Dexamethasone
    • Vincristine
    • Doxorubicin
  • Exploring sacituzumab govitecan for HER2-negative breast cancer care

    This study is evaluating a new treatment for patients with a certain type of breast cancer (HER2-negative) who have not had a complete response to initial chemotherapy. Participants are randomly assigned to receive the investigational drug sacituzumab govitecan or a treatment of their physician’s choice, which may be another type of chemotherapy with capecitabinalub, carboplatin or cisplatin. The study is designed to compare the effectiveness of these approaches in preventing cancer recurrence. Patients may also receive hormone therapy if needed. Patients’ safety and response to treatment are being closely monitored throughout the study.

    • Sacituzumab govitecan
    • Carboplatin
    • Cisplatin
    • Capecitabine

See more clinical trials in other cities in France:

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