Clinical trials located in

Birmingham

Birmingham city is located in United Kingdom. Currently, 20 clinical trials are being conducted in this city.

Birmingham, located in the heart of England, is the UK’s second-largest city. Known for its rich industrial heritage, it played a pivotal role in the Industrial Revolution. The city boasts more miles of canals than Venice, offering a unique urban landscape. Birmingham is also the birthplace of the Balti curry, highlighting its diverse culinary scene. The Birmingham Library, with its modern architecture, stands as one of the largest public libraries in Europe. Additionally, it has a vibrant cultural scene, including the Birmingham Royal Ballet and the Symphony Orchestra.

  • CT-EU-00119402

    Study of infigratinib in children with achondroplasia

    The clinical study involves children with achondroplasia who previously participated in the PROPEL study. The study evaluates infigratinib, an oral tablet medication. The goal is to assess the safety, tolerance, and effectiveness of the drug. Infigratinib targets the fibroblast growth factor receptor (FGFR), which is crucial in processes like cell growth, wound healing, and bone and blood vessel formation.

    The study is aimed at children aged 3 to 11 years who can walk unaided and take oral medication. Various doses will be adjusted based on the child’s weight. The study will assess changes in annual height growth, pharmacokinetic parameters (such as maximum drug concentration in the blood), and any adverse events. Additionally, changes in body proportions, limb length, and other growth measures will be analyzed.

    • Infigratinib
  • Testing Vemurafenib and Cobimetinib for BRAF Positive Cancers

    This clinical trial is for patients with cancers that have a specific change in their cancer cells known as BRAF V600 mutation. It uses two drugs, vemurafenib and cobimetinib, to see if they can effectively treat various types of cancers such as solid tumors, haematological malignancies, melanoma, thyroid cancer, ovarian neoplasms, colorectal neoplasms, laryngeal neoplasms, non-small-cell lung carcinoma, glioma, multiple myeloma, and Erdheim-Chester disease. The purpose of this study is to determine if these drugs can help treat cancers with the BRAF V600 mutation.

    In the study, participants will receive both drugs until their disease progresses, they experience unacceptable side effects, or they decide to withdraw. Blood samples will be collected at different times during the treatment for research purposes. Participants will be monitored every three months for two years after completing the treatment.

    • Vemurafenib
    • Cobimetinib
  • Long-term safety and efficacy study of PTC518 for Huntington’s disease

    This study focuses on Huntington’s Disease and evaluates the long-term safety and effectiveness of the drug PTC518. Participants, who have previously completed related study phases, will continue taking PTC518 in doses of 5, 10, or 20 milligrams. The study aims to monitor the safety of long-term use and assess how the drug impacts biological markers and symptoms of the disease over a period of 30 months. This is an extension study where all participants will receive the active drug, ensuring continuous monitoring and evaluation of its effects.

    • PTC518
  • Study on SAGE-718 for improving cognitive function in Huntington’s disease

    This study focuses on Huntington’s Disease and aims to evaluate the effect of SAGE-718 on cognitive performance and functioning. Huntington’s Disease is a genetic disorder that affects the brain and leads to cognitive decline and motor dysfunction. The study will involve the drug SAGE-718 and a placebo. The primary goal is to understand how SAGE-718 impacts cognitive abilities in participants with Huntington’s Disease over 84 days. Participants will be randomly assigned to receive either the drug or a placebo daily, and their cognitive performance will be assessed using various tests.

    • SAGE-718
    • placebo
  • Study comparing INBRX-101 and Zemaira for Alpha-1 Antitrypsin Deficiency-Related Emphysema

    This clinical study focuses on Alpha-1 Antitrypsin Deficiency (AATD), a genetic condition that can lead to lung diseases such as emphysema. AATD is caused by low levels of the protein alpha-1 antitrypsin (AAT), which helps protect the lungs from damage.

    The study compares two treatments: INBRX-101, a new investigational drug, and a standard therapy using plasma-derived Alpha1-Proteinase Inhibitor (A1PI), commonly known as Zemaira. INBRX-101 is designed to maintain higher and more stable levels of AAT in the blood than current treatments, potentially providing better protection for the lungs over time.

    The purpose of the study is to evaluate the effectiveness, safety, and how the body processes these treatments. Participants will receive either INBRX-101 or the standard A1PI therapy, with neither the participants nor the doctors knowing which treatment each person is getting (this is called a double-blind study).

    Participants will go through a screening phase to ensure they meet the study criteria. If they are currently on other A1PI therapies, they will need a break period (washout phase) before starting the treatment phase, which lasts about 32 weeks. During this time, participants will receive their assigned treatment regularly and undergo various health assessments, including blood and urine tests, lung function tests, and imaging studies like CT scans. The study will also include some additional sub-studies to gather more detailed data on how the treatments work in the body.

    The study aims to gather important information that could lead to better treatment options for people with AATD and related lung diseases. It will help determine if INBRX-101 offers a significant improvement over the current standard treatment.

    • INBRX-101
    • Zemaira
  • Testing of a new antibody (RO7247669) in patients with metastatic cancers

    This clinical trial is testing a new drug called RO7247669. This is a special type of antibody that targets two proteins in cancer cells, PD-1 and LAG-3. The goal is to see if this new drug can help fight advanced or metastatic solid tumors such as melanoma, lung cancer and esophageal cancer.

    In the first part of the study, researchers will administer different doses of RO7247669 to patients every 2 or 3 weeks through a drip. They will watch closely for any side effects and toxicities that may occur. Once they determine the highest safe dose, they will move on to the next section.

    In the second part, they will give the highest safe dose to more patients with a specific type of cancer. The most important thing they will look for will be how well the drug works against the tumors, such as whether they shrink for a while or stop growing. They will also monitor you for any side effects for up to 2 years.

    The aim of this study is to find the best and safest dose of this new dual-acting antibody drug and whether it will be able to effectively fight advanced solid tumors.

    • RO7247669
  • Study assessing the effectiveness of Tebentafusp administered alone and in combination with Pembrolizumab in the treatment of advanced melanoma

    The aim of this study is to test new treatments for people with advanced skin melanoma that does not respond well to other therapies. The main focus was on a new experimental drug called tebentafusp, which is a special type of protein that helps the body’s immune system recognize and attack cancer cells.

    The study divided patients into three different groups. One group will receive tebentafusp alone. Another group will receive tebentafusp in combination with another immunotherapy drug called pembrolizumab. The third group will receive the treatment that the doctor thinks is best for the patient – this could be another experimental drug, standard therapy, or simply supportive care.

    Scientists are primarily focusing on the effectiveness of these treatments in shrinking tumors and extending patient survival. They will also monitor closely for any side effects to make sure the treatment is safe. The study is expected to last about two years and will include frequent check-ins to monitor patient responses.

    • Tebentafusp
    • Pembrolizumab
  • Comparing ruxolitinib, hydroxycarbamide, and Interferon as first-line treatments for high-risk Polycythemia Vera

    The study, known as MITHRIDATE, investigates the effectiveness of the drug Ruxolitinib compared to either Hydroxycarbamide or Interferon Alpha for patients with high-risk Polycythemia Vera, a type of blood disorder. This Phase III clinical trial aims to determine which treatment is more effective in managing the disease without leading to additional health complications.

    Patients in the trial are assigned to receive either Ruxolitinib or the best available therapy, chosen from Hydroxycarbamide or Interferon Alpha, as decided by the overseeing doctors. The course of the study involves regular monitoring and assessments to evaluate the impact of these treatments on the disease’s progression and patients’ overall health and quality of life. The study is conducted in a controlled environment to ensure reliable results.

    • Interferon-Alpha
    • Hydroxycarbamide
    • Ruxolitinib
  • Exploring the Impact of ATL1102 in Boys with Duchenne Muscular Dystrophy

    This study is designed to test the effectiveness and safety of a new treatment called ATL1102. The trial is specifically for boys aged 10 to <18 who cannot walk (non-ambulatory).

    The study is divided into two main parts. In the first part, participants will be randomly assigned to receive either ATL1102 at doses of 25 mg or 50 mg, or a placebo (a treatment with no active drug), given as a weekly subcutaneous injection. This phase will last for 24 weeks and is double-blind, meaning neither the participants nor the researchers will know who is receiving the actual drug or the placebo.

    Following this, all participants will move into the second part of the study, where they will receive ATL1102 for another 24 weeks. This part is open-label, which means everyone will know they are receiving the active drug.

    The main goal of the study is to see how well ATL1102 can improve upper limb strength, which is crucial for daily activities. This will be measured using the Performance of Upper Limb (PUL) 2.0 score, a tool designed to assess upper limb strength in individuals with DMD.

    • ALT1102
  • CT-EU-00091258

    Study of Idasanutlin in combination with chemotherapy or other drugs in acute leukemia patients

    This study involves testing a new medication, Idasanutlin, for patients with recurrent or challenging-to-treat leukemias or solid tumors. In certain cases, the new medication will be administered in combination with other anti-cancer drugs, either traditional chemotherapy medications or Venetoclax. The primary objective is to assess the medication for potential side effects and its effectiveness in treating the disease. Initially, efforts will focus on determining a safe and well-tolerated dose for the new medication. Subsequently, the study will further investigate the safety and initial effectiveness of combining this drug with others in three groups: neuroblastoma, acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL).

    • Idasanutlin
    • Cytarabine
    • Fludarabine
    • topotecan
    • Cyclophosphamide
    • Venetoclax
  • Testing a new drug for advanced prostate cancer

    This trial compares a new drug called AZD5305 with a placebo in men who have a specific kind of prostate cancer that has not responded to usual treatment methods. It’s a large trial, with around 1800 participants, and the main aim is to see whether the new treatment can help slow down the disease for longer than current treatments. Participants will be assigned to two different groups, and they will not know whether they’re receiving the real drug or the placebo. Their health will be monitored closely, with regular scans to check the progress of the cancer. The trial will also look at any side effects of the treatment and how it affects the patients’ ability to do their daily activities.

    • Enzalutamide/Xtandi
    • Darolutamide/Nubequa
    • Abiraterone Acetate/Zytiga
    • Saruparib
  • Continued Parsaclisib treatment for B-cell cancer patients

    This is a phase II clinical trial focused on providing continuation of treatment with a drug called parsaclisib to people diagnosed with B-cell malignancies. The main goal of this study is to expand the treatment regimen established in the previous study. Study participants will receive parsaclisib as a stand-alone therapy (monotherapy) or in combination with other therapeutic agents, which may include itacitinib, ruxolitinib or ibrutinib. The study aims to facilitate participants’ ongoing care and contribute to the broader field of medical research by collecting data on the effectiveness and safety of prolonged use of parsaclisib.

    • Ibrutinib
    • Ruxolitinib
    • Itacitinib
    • Parsaclisib
  • Stomach cancer treatment comparison: trastuzumab deruxtecan vs. ramucirumab & paclitaxel

    This is a thorough comparison study to measure the effectiveness and safety of two treatment paths. It’s designed for individuals who have experienced progression regarding a stomach (gastric) cancer, or cancer of the gastro-esophageal junction (GEJ). The study focuses on those with HER2-positive gastric or GEJ who have previously undergone a trastuzumab-containing regime but have not received further systemic therapy.The research compares the use of trastuzumab deruxtecan, a potent anti-cancer agent, and the combined use of ramucirumab and paclitaxel. The study’s primary goal is to evaluate the overall survival rate, while secondary aims involve examining progression-free survival, response duration, disease control, safety, pharmacokinetics, and immunogenicity.In the study, participants are fairly and randomly assigned to receive one of two treatments. This is crucial in understanding the superiority and safety of these treatment paths, and this knowledge may inform future approaches to treating these types of cancer.

    • Ramucirumab
    • Trastuzumab deruxtecan
    • Paclitaxel
  • Exploring the safety of seladelpar in treating primary biliary cholangitis

    This is a long-term study on a drug named seladelpar for people with a liver disease called Primary Biliary Cholangitis (PBC). The main goal is to see if this drug is safe and easy for patients with PBC to use over a long period. A secondary goal is to see if seladelpar can effectively treat PBC and improve the patient’s quality of life. The study will track a few things, like if there are changes in the patient’s liver health which may lead to hospitalization or if the patient’s liver enzymes like alkaline phosphate and bilirubin level normalize or not after taking this drug.

    • Seladelpar
  • Studying efficacy of volrustomig for metastatic lung cancer

    The study compared two treatments for metastatic non-small cell lung cancer: volrustomig with chemotherapy and pembrolizumab with chemotherapy. Its purpose is to determine which combination is more effective and safer. Patients will be divided into two groups. One group will receive volrustomig and chemotherapy, and the other group will receive pembrolizumab and chemotherapy. The effectiveness of treatment in each group will then be tracked using imaging tests. In addition, a group of researchers will follow each participant until the end of the study to make sure the treatment is safe and tolerable.

    • Volrustomig
    • Pemetrexed
    • Carboplatin
    • Pembrolizumab
    • Paclitaxel
  • Trial for high-risk Lymphoma Patients comparing Axicabtagene Ciloleucel and standard therapy

    In this study, the researchers are trying to find out if a new drug called Axicabtagene Ciloleucel is a better first treatment for a type of blood cancer known as high-risk large B-cell lymphoma, compared to the current standard treatment. This is a big study, done in many places, where patients will be randomly picked to get either the new drug or the current standard treatment. Five years after the last patient joins the study, those who had the new drug will join another study to see how they are doing for the next 10 years. The study will look at a few things, like how long until the disease gets worse, how many people’s cancer has gone away after the treatment, and how their quality of life and health status are, using different questionnaires.

    • Axicabtagene Ciloleucel
    • Prednisone
    • Fludarabine
    • Vincristine
    • Doxorubicin
    • Etoposide
    • Cyclophosphamide
    • Rituximab
  • A comprehensive evaluation of retatrutide in obesity and associated comorbidities

    This study evaluates the effectiveness and safety of a new drug, retatrutide, in individuals with obesity or overweight, including those with knee osteoarthritis or obstructive sleep apnea. Lasting about 89 weeks, the trial involves randomized assignment of participants to either receive retatrutide or a placebo. The main goals are to observe changes in body weight, knee pain in osteoarthritis, and sleep apnea severity. The study also examines various secondary outcomes like changes in BMI, waist circumference, and blood pressure. The trial aims to provide new insights into weight management and associated health conditions, offering hope for improved treatments.

    • Retatrutide
  • Osimertinib effectiveness study for early-stage lung cancer post-surgery

    This study is examining the effects of osimertinib on patients with a specific type of early-stage lung cancer (EGFRm stage IA2-IA3 non-small cell lung cancer) after complete tumor removal surgery. It’s a Phase III trial comparing osimertinib, a new drug, with a placebo. Participants, who have already had surgery for their lung cancer, will either receive osimertinib or a placebo daily for three years. The goal is to see if osimertinib can prevent cancer from coming back and improve patients’ survival rates.

    • Osimertinib
  • Exploring treatment options for newly diagnosed Multiple Myeloma

    This clinical trial investigates two treatment paths for newly diagnosed multiple myeloma patients who are not planned for stem cell transplant initially. The first group receives a combination of bortezomib, lenalidomide, and dexamethasone (VRd) followed by cilta-cel, an innovative therapy. The second group receives VRd followed by continued treatment with lenalidomide and dexamethasone (Rd). The study evaluates the effectiveness of these treatments by monitoring disease progression, treatment response, and patient survival rates. It also assesses the safety and side effects of the treatments, aiming to improve the quality of life and outcomes for patients with multiple myeloma. The trial’s objective is to provide valuable data on the potential benefits of integrating cilta-cel in the treatment regimen, compared to the more traditional approach, offering insights for better management of this challenging cancer.

    • Cilta-cel
    • Fludarabine
    • Lenalidomide
    • Dexamethasone
    • Cyclophosphamide
    • Bortezomib
  • Evaluating dostarlimab for treating stage III colon cancer

    This research is focused on the investigation of the effect of dostarlimab on patients with severe, untreated colon cancer (T4N0 or Stage III dMMR/MSI-H). The primary objective is to assess whether dostarlimab yields superior outcomes for the patients in comparison to standard treatments. Patient monitoring will be based on tumor response and the potential impact on their quality of life resulting from the drug or disease progression.

    • CAPEOX
    • Dostarlimab
    • FOLFOX

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