Muscle-invasive bladder cancer is a form of bladder cancer that has grown into the muscle layer of the bladder wall. Treatment often involves a major operation called radical cystectomy, in which the bladder is removed, followed by neobladder reconstruction that creates a new bladder using a piece of intestine. In this study, the new bladder is helped by a therapy named InvivoLPrint-U, which uses a patient’s own (autologous) bladder‑lining cells that are grown in a laboratory and placed into the new bladder with a special printer.
The purpose of the study is to collect additional data on the long‑term safety of this therapy after the initial surgery. Participants who completed the earlier trial will be monitored for several years with regular visits that include urine checks, imaging scans, and questionnaires about daily life and bladder control. During follow‑up, doctors will look for serious problems such as death, rejection of the new bladder, or the need for another operation, as well as issues like infections, urinary leakage, stone formation, and changes in blood chemistry that could cause metabolic acidosis. Quality of life will also be assessed using a standard questionnaire.
Greece 
