This clinical trial is focused on studying treatments for people with uncontrolled hypertension (high blood pressure) who also have moderate to severe chronic kidney disease. The study will explore the effectiveness of different medications, specifically a group of drugs known as diuretics, which help the body get rid of excess salt and water. The medications being tested include Amiloride Hydrochloride, Indapamide, Furosemide, and Hydrochlorothiazide. These medications are commonly used to help lower blood pressure and manage fluid levels in the body.

The purpose of the study is to see if using these diuretics can help reduce the risk of worsening kidney disease, heart problems, and other serious health issues in people with both high blood pressure and chronic kidney disease. Participants in the study will be randomly assigned to receive either the diuretic treatment or the usual management for their condition. The study will last for up to 36 months, during which time participants will have regular check-ups to monitor their health and the effects of the treatment.

Throughout the study, researchers will track various health outcomes, such as the progression of kidney disease, the occurrence of heart-related events like heart attacks or strokes, and overall survival rates. The study aims to provide valuable information on whether intensifying blood pressure treatment with diuretics can offer better health outcomes for patients with these conditions. Participants will also be monitored for any side effects or safety concerns related to the medications used in the trial.