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Pantothenate Sodium

This article discusses a clinical trial investigating the use of a vitamin supplement containing Pantothenate Sodium, along with other vitamins, in patients with cardiogenic shock. The study aims to evaluate the effectiveness of levosimendan, a heart medication, in combination with conventional treatments for this serious cardiac condition. While the primary focus is on levosimendan, the vitamin supplement Soluvit, which includes Pantothenate Sodium, is used as part of the overall treatment strategy.

Table of Contents

What is Pantothenate Sodium?

Pantothenate Sodium is a form of vitamin B5, also known as pantothenic acid. It is one of the essential components found in a multivitamin solution called SOLUVIT, which is used for intravenous (IV) administration[1]. This vitamin plays a crucial role in many bodily functions, including energy production and the synthesis of important molecules in our body.

Medical Use

SOLUVIT, which contains Pantothenate Sodium, is primarily used in medical settings where patients require nutritional support through intravenous means. This could include situations such as:

  • Patients who cannot eat or absorb nutrients normally
  • Individuals recovering from certain surgeries
  • Patients with severe illnesses or conditions that affect nutrition

The multivitamin solution helps to prevent vitamin deficiencies in these patients by providing essential vitamins directly into their bloodstream[1].

Administration

SOLUVIT, containing Pantothenate Sodium, is administered through intravenous infusion. This means it is given directly into a vein, usually through a drip or IV line. The solution comes as a lyophilisate for parenteral use, which is a freeze-dried powder that needs to be reconstituted before use[1].

Clinical Trial Information

It’s important to note that the clinical trial information provided does not specifically focus on Pantothenate Sodium or SOLUVIT. The trial described is actually about a different medication called levosimendan, used for treating cardiogenic shock[1]. However, this information gives us insight into how clinical trials are conducted and the types of patients who might require nutritional support through IV solutions.

Other Components in the Multivitamin Solution

SOLUVIT is a complex multivitamin solution that contains several other important vitamins besides Pantothenate Sodium. These include[1]:

  • Riboflavin Sodium Phosphate: A form of vitamin B2
  • Biotin: Also known as vitamin B7
  • Cyanocobalamin: A form of vitamin B12
  • Folic Acid: Also known as vitamin B9
  • Nicotinamide: A form of vitamin B3
  • Sodium Ascorbate: A form of vitamin C
  • Thiamine Nitrate: A form of vitamin B1
  • Pyridoxine Hydrochloride: A form of vitamin B6

Each of these vitamins plays a crucial role in maintaining various bodily functions and overall health.

Safety and Considerations

While SOLUVIT and its components, including Pantothenate Sodium, are generally safe when used as prescribed, there are some important points to consider:

  1. This product should only be administered by healthcare professionals in appropriate medical settings.
  2. The dosage is carefully calculated based on the patient’s individual needs and condition.
  3. As with any medical treatment, there may be potential side effects or interactions with other medications.
  4. Patients with specific allergies or medical conditions may not be suitable candidates for this treatment.

Always consult with a healthcare provider for personalized medical advice and information about treatments involving intravenous nutrition or vitamin supplementation[1].

Aspect Details
Study Type Phase III clinical trial
Main Condition Cardiogenic Shock
Primary Intervention Levosimendan vs Placebo
Vitamin Supplement Soluvit (containing Pantothenate Sodium)
Primary Endpoint 30-day mortality and/or need for ECLS and/or dialysis
Follow-up Duration 12 months
Key Inclusion Criteria Adult patients with cardiogenic shock, receiving specific doses of norepinephrine or dobutamine
Key Exclusion Criteria Cardiac arrest with specific conditions, immediate need for ECLS, chronic renal failure requiring hemodialysis

FAQ

  • What is the main purpose of this clinical trial? The main purpose of this clinical trial is to evaluate the effect of early use of levosimendan compared to placebo, in addition to conventional inotrope treatment, on a combined morbidity-mortality endpoint in patients with cardiogenic shock.
  • How is Pantothenate Sodium involved in this study? Pantothenate Sodium is one of the active ingredients in Soluvit, a vitamin supplement used in the study. While not the primary focus, it is part of the overall treatment strategy for patients with cardiogenic shock.
  • What are the main inclusion criteria for participants? The main inclusion criteria are: adult patients (18 years or older) with cardiogenic shock, adequate intravascular volume, and receiving specific doses of norepinephrine or dobutamine for at least 3 hours but less than 24 hours.
  • What is the primary endpoint of the study? The primary endpoint is all-cause mortality and/or need for ExtraCorporeal Life Support (ECLS) and/or dialysis at day 30 following randomization.
  • How long will participants be followed in this study? Participants will be followed for 12 months after inclusion and randomization in the study.

Ongoing Clinical Trials on Pantothenate Sodium

  • Study on Faster Weaning from Ventilators in Critically Ill Patients Using Levosimendan and a Drug Combination

    Recruiting

    3 1 1
    Investigated diseases:
    Investigated drugs:
    The Netherlands

  • Study on the Early Use of Levosimendan Compared to Placebo for Patients with Cardiogenic Shock

    Recruiting

    3 1 1
    Investigated diseases:
    Investigated drugs:
    France

Glossary

  • Cardiogenic Shock: A serious condition where the heart suddenly can't pump enough blood to meet the body's needs, often due to a severe heart attack.
  • Levosimendan: A medication used to treat acute heart failure by improving the heart's ability to pump blood.
  • Inotrope: A type of medication that changes the force of heart muscle contractions.
  • ExtraCorporeal Life Support (ECLS): A technique that uses a machine to take over the function of the heart and lungs when these organs are severely damaged.
  • Pantothenate Sodium: A form of vitamin B5 used in nutritional supplements, important for many bodily functions including energy production.
  • Soluvit: A vitamin supplement containing multiple vitamins, including Pantothenate Sodium, used for intravenous nutrition.
  • Norepinephrine: A medication used to treat very low blood pressure, especially in emergency situations.
  • Dobutamine: A medication used to treat heart failure by increasing the strength of heart contractions.
  • Morbidity: The state of being ill or having a disease.
  • Mortality: Death, especially on a large scale or from a specific cause.

References

  1. http://clinicaltrials.eu/trial/study-on-the-early-use-of-levosimendan-compared-to-placebo-for-patients-with-cardiogenic-shock/