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Adrenaline Acid Tartrate Bp

This article discusses the use of Adrenaline Acid Tartrate BP in clinical trials for patients undergoing robot-assisted upper urologic surgery. The study aims to improve post-operative recovery by combining spinal analgesia with general anesthesia. We’ll explore the trial’s objectives, eligibility criteria, and potential benefits for patients with various kidney and ureter conditions.

Table of Contents

What is Adrenaline Acid Tartrate BP?

Adrenaline Acid Tartrate BP, also known as Epinephrine Acid Tartrate BP, is a medication that belongs to a class of drugs called catecholamines[1]. It is a form of adrenaline, which is a hormone naturally produced by our bodies in response to stress or excitement. The “BP” in its name stands for “British Pharmacopoeia,” indicating that it meets specific quality standards.

Medical Uses

Adrenaline Acid Tartrate BP is used in various medical situations, often in combination with other medications. In the context of the clinical trial discussed here, it is being used alongside Bupivacaine Hydrochloride for spinal anesthesia in patients undergoing robot-assisted upper urinary tract surgery[1].

This medication can be used in the treatment of several conditions related to the urinary system, including:

  • Renal or ureter malignancy: Cancers of the kidney or ureter
  • Renal or ureter benign tumor: Non-cancerous growths in the kidney or ureter
  • Nephrolithiasis: Kidney stones
  • Renal reflux: A condition where urine flows backward from the bladder to the kidneys

Administration

In the clinical trial, Adrenaline Acid Tartrate BP is administered intrathecally[1]. This means it is injected directly into the fluid surrounding the spinal cord. This method of administration is used to provide spinal anesthesia, which numbs the lower part of the body during surgery.

Clinical Trial Information

The medication is being studied in a Phase III clinical trial called “SMILe: Spinal Morphine or Intravenous Lidocaine in robot-assisted upper urologic surgery”[1]. This trial aims to investigate whether adding spinal analgesia (pain relief) with bupivacaine and morphine to general anesthesia can improve recovery after robot-assisted laparoscopic upper urinary tract surgery.

Potential Benefits

The researchers are studying whether the use of this medication combination can lead to several potential benefits for patients, including:

  • Improved recovery after surgery
  • Less pain
  • Faster mobilization (ability to move around)
  • Shorter hospital stay
  • Fewer complications

They are also investigating its effects on factors such as blood pressure during surgery and markers of inflammation in the body[1].

Considerations and Precautions

While Adrenaline Acid Tartrate BP can be beneficial in certain medical situations, it’s important to note that it may not be suitable for everyone. The clinical trial has specific inclusion and exclusion criteria. For example, patients with severe heart problems, kidney failure, or liver disease may not be eligible to receive this medication in the trial[1].

It’s crucial to always consult with your healthcare provider about the potential risks and benefits of any medication or medical procedure. They can provide personalized advice based on your individual health status and medical history.

Aspect Details
Trial Name SMILe: Spinal Morphine or Intravenous Lidocaine in robot-assisted upper urologic surgery
Main Objective To study the effects of adding spinal analgesia with bupivacaine and morphine to general anesthesia in robot-assisted laparoscopic upper urinary tract surgery
Primary Outcome QoR-15 score at postoperative day 1
Medical Conditions Renal or ureter malignancy, benign tumors, nephrolithiasis, renal reflux
Key Medication Adrenaline Acid Tartrate BP, Bupivacaine
Administration Route Intrathecal use
Secondary Outcomes Pain levels, mobilization speed, length of stay, complications, intraoperative hemodynamics, inflammatory markers

FAQ

  • What is the main purpose of this clinical trial? The main purpose is to study whether adding spinal analgesia with bupivacaine and morphine to general anesthesia improves recovery after robot-assisted laparoscopic upper urinary tract surgery. This is measured using a patient-centered outcome scale called 'Quality of Recovery 15'.
  • What medical conditions are being studied in this trial? The trial focuses on patients with renal or ureter malignancy, benign tumors, nephrolithiasis (kidney stones), and renal reflux. These conditions affect the kidneys and ureters.
  • Who is eligible to participate in this clinical trial? Eligible participants are patients scheduled for elective robot-assisted upper urinary tract surgery at participating hospitals. They must provide informed consent after receiving information about the study. However, there are several exclusion criteria, such as being a minor, having severe psychiatric disease, or having contraindications to spinal analgesia.
  • What is Adrenaline Acid Tartrate BP used for in this trial? Adrenaline Acid Tartrate BP is used as part of the spinal analgesia mixture, along with bupivacaine. It is administered intrathecally (into the spinal fluid) to potentially improve post-operative recovery and pain management.
  • What are some of the outcomes being measured in this trial? The trial measures various outcomes, including pain levels, time spent out of bed, length of hospital stay, postoperative complications, opioid requirements, and several intraoperative factors such as blood pressure and cardiac function. The primary outcome is the QoR-15 score on the first day after surgery.

Ongoing Clinical Trials on Adrenaline Acid Tartrate Bp

  • Comparing spinal morphine and epidural drug combination for pain relief in patients having open colorectal surgery

    Not yet recruiting

    3 1 1 1
    Investigated drugs:
    Sweden

Glossary

  • Intrathecal: Referring to the space under the arachnoid membrane of the brain or spinal cord, where cerebrospinal fluid circulates. In this trial, it refers to the administration of medication directly into the spinal fluid.
  • Bupivacaine: A local anesthetic medication used to numb an area of the body. In this trial, it's used as part of the spinal analgesia mixture.
  • Robot-assisted laparoscopic surgery: A minimally invasive surgical technique that uses small incisions and a camera, with the added precision of robotic technology controlled by a surgeon.
  • Spinal analgesia: A method of pain relief that involves injecting medication into the fluid surrounding the spinal cord.
  • QoR-15: Quality of Recovery 15, a patient-centered outcome scale used to measure recovery after surgery.
  • Nephrolithiasis: The medical term for kidney stones, which are hard deposits of minerals and salts that form inside the kidneys.
  • Renal reflux: A condition where urine flows backward from the bladder into the kidneys, potentially causing kidney damage.
  • ASA class: American Society of Anesthesiologists physical status classification system, used to assess a patient's pre-operative physical condition.
  • PACU: Post-Anesthesia Care Unit, a specialized area for patients recovering from anesthesia after surgery.
  • PONV: Post-Operative Nausea and Vomiting, a common side effect after surgery and anesthesia.

References

  1. http://clinicaltrials.eu/trial/study-on-spinal-morphine-intravenous-lidocaine-and-bupivacaine-for-patients-undergoing-robot-assisted-surgery-for-kidney-or-ureter-conditions/