Cardiovascular Diseases and Thrombosis Research

At Stichting Radboud University Medical Center in Nijmegen, a major share of the Cardiology portfolio focuses on cardiovascular diseases such as atrial fibrillation, acute coronary syndrome, myocardial infarction, hypertension, and broader atherosclerotic cardiovascular disease. These studies are designed to test new ways to prevent serious heart and blood-vessel events, improve treatment choices, and reduce complications after cardiac illness or surgery.

  • Prevention of stroke and other embolic events in atrial fibrillation
  • Reducing major cardiovascular risk in patients with atherosclerotic disease
  • Improving recovery and safety after heart attack and other acute cardiac events
  • Evaluating treatments for venous thrombosis and clot-related disorders

The site is also involved in research on better diagnostic approaches and treatment strategies, including imaging and medication studies, to support more personalized cardiology care.

Oncology and Hematology

Research at this hospital-based site includes a broad range of cancer and blood cancer trials, covering prostate cancer, lung cancer, head and neck cancer, renal cell carcinoma, gastrointestinal stromal tumor, and rare hematologic malignancies such as lymphoma, leukemia, and myelodysplastic syndrome. The goal is to evaluate new therapies, improve survival, and better control disease progression in difficult-to-treat cancers.

  • Testing new treatment options for advanced and metastatic solid tumors
  • Studying novel approaches for lymphoma, leukemia, and other rare blood cancers
  • Improving outcomes in prostate cancer and renal cancer
  • Assessing therapies for head and neck, lung, and gastrointestinal malignancies

Several studies also focus on treatment effectiveness after prior therapy, helping clarify which options may offer the best balance of benefit and safety for patients with advanced disease.

Gastroenterology, Hepatology, and Inflammatory Bowel Disease

The site conducts important trials in digestive system diseases, especially Crohn’s disease, ulcerative colitis, chronic pancreatitis, and polycystic liver disease. This research aims to improve symptom control, maintain remission, and explore better long-term management strategies for chronic gastrointestinal and liver conditions.

  • Evaluating therapies for ulcerative colitis and Crohn’s disease
  • Studying pain relief and quality-of-life support in chronic pancreatitis
  • Testing treatments for polycystic liver disease
  • Assessing maintenance options for ongoing inflammatory bowel disease care

These studies are aimed at helping patients achieve more stable disease control while reducing the burden of long-term gastrointestinal illness.

Nephrology and Immune-Mediated Kidney Disease

Clinical trials here also address kidney disease linked to immune and inflammatory conditions, including IgA nephropathy, C3 glomerulopathy, immune complex membranoproliferative glomerulonephritis, anti-GBM antibody disease, and other forms of renal injury. The main purpose is to protect kidney function, slow disease progression, and evaluate whether new therapies can improve outcomes in patients with complex renal disorders.

  • Testing treatments for glomerular disease and immune-related kidney injury
  • Exploring ways to preserve renal function in high-risk patients
  • Studying new options for anti-GBM disease and other severe nephrology conditions
  • Assessing treatment benefit in chronic proteinuric kidney disease

Research in this area reflects a strong interest in both disease control and long-term kidney protection.

Neurology, Psychiatry, and Rare Neuromuscular Disease

The research portfolio includes studies in Parkinson’s disease, Duchenne muscular dystrophy, and behavior-related disorders such as GHB use disorder. These trials focus on understanding disease progression, improving symptom management, and supporting better day-to-day functioning for patients and families.

  • Investigating treatments for early Parkinson’s disease
  • Studying long-term support for Duchenne muscular dystrophy
  • Evaluating approaches to substance use disorder and detoxification support
  • Exploring strategies to improve neurological and behavioral outcomes

This work combines treatment research with efforts to better understand how chronic neurological conditions affect quality of life over time.

Rare Diseases, Endocrinology, and Metabolic Disorders

Stichting Radboud University Medical Center is also active in trials for classic congenital adrenal hyperplasia, familial partial lipodystrophy, severe hypertriglyceridemia, and related metabolic disorders. The main aim is to evaluate therapies that may improve hormone balance, metabolic health, and long-term disease control in conditions that often require specialized care.

  • Testing treatments for adrenal hormone imbalance
  • Studying therapies for lipodystrophy and abnormal fat metabolism
  • Evaluating approaches for severe lipid disorders
  • Supporting better management of complex rare endocrine disease

These studies help expand options for patients with uncommon conditions where effective long-term treatment remains limited.

Ophthalmology and Sensory Disorders

Eye-related research at the site includes trials in geographic atrophy and retinitis pigmentosa, two serious conditions that can lead to progressive vision loss. The studies are designed to assess whether new therapies can slow deterioration, preserve visual function, and improve the outlook for people living with inherited or age-related eye disease.

  • Testing treatments to slow progression of geographic atrophy
  • Evaluating options to preserve vision in retinitis pigmentosa
  • Studying long-term visual function and safety outcomes
  • Improving care for patients with chronic retinal disease

These trials reflect a strong focus on maintaining eyesight and delaying disability caused by retinal degeneration.

Infectious Diseases and Immunology

Another important area of research involves infectious disease and immune system studies, including COVID-19, Staphylococcus aureus bacteremia, sepsis, and herpes zoster. The purpose of these trials is to improve infection management, reduce complications, and better understand how the immune system responds in vulnerable patients.

  • Evaluating treatments for serious bacterial infections
  • Studying outcomes in sepsis and bloodstream infection
  • Exploring immune response and protection in COVID-19
  • Assessing prevention and treatment strategies for viral disease

Work in this area supports both acute care and prevention, especially for patients at higher risk of infection-related harm.

Diagnostics, Imaging, and Treatment Support

Some trials at the site focus on diagnostic techniques and supportive treatment tools rather than a single disease area. This includes imaging for prostate cancer, methods to guide safer medication use, and approaches to prevent treatment-related complications such as hearing loss or kidney damage. The goal is to make care more precise, safer, and more effective across multiple specialties.

  • Improving detection of cancer spread with advanced imaging
  • Testing ways to reduce therapy-related toxicity
  • Supporting more accurate and individualized treatment decisions
  • Assessing tools that help protect kidney and hearing function

These studies show a strong interest in research that strengthens both diagnosis and supportive care across the wider clinical trial portfolio.