This clinical trial focuses on patients with Multiple Myeloma, a type of blood cancer that affects plasma cells in the bone marrow. The study investigates a combination treatment approach using three medications: daratumumab, teclistamab, and talquetamab. These medications are given as solutions for injection under the skin (subcutaneous injection).
The main purpose of this research is to evaluate how well patients respond to treatment over an 18-month period. The study specifically targets newly diagnosed patients who have not received any previous treatment and are considered frail according to medical assessment criteria. Patients will be divided into two groups – one receiving daratumumab with teclistamab, and the other receiving daratumumab with talquetamab.
During the study, patients will receive their assigned combination of medications through injections under the skin. The treatment will continue while monitoring how well the cancer responds and checking for any side effects. The medications work by helping the body’s immune system fight against the cancer cells. Regular medical check-ups and tests will be performed to track the progress of the treatment.



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