This study focuses on patients with colorectal cancer that has spread or cannot be removed by surgery. The research evaluates a new combination treatment approach using several medications. The main drug being studied is futibatinib, which is given as tablets, along with tislelizumab (given through an infusion into a vein) and additional chemotherapy medications including fluorouracil, oxaliplatin, and calcium folinate.
The purpose of the study is to determine how effective this combination of medications is when used as a first treatment for colorectal cancer. During the study, participants will receive the study medications for up to 12 months. Futibatinib is taken by mouth daily, while the other medications are given through intravenous infusions at regular intervals.
Throughout the study, doctors will monitor how the cancer responds to treatment using imaging scans. They will also track any side effects and assess how the treatment affects patients’ quality of life. The study will evaluate whether tumors shrink or disappear with this treatment combination, how long any improvements last, and how long patients live without their cancer getting worse.



Germany