This clinical trial is focused on studying the effects of a new treatment called patritumab deruxtecan (also known by its code name MK-1022) in children with certain types of cancer. The specific cancers being studied are hepatoblastoma and rhabdomyosarcoma, which are types of solid tumors that have either returned after treatment or have not responded to previous treatments. The purpose of the study is to evaluate the safety and effectiveness of this new treatment in these young patients.
The study will involve administering patritumab deruxtecan to participants through an intravenous infusion, which means the medication is given directly into a vein. The trial will be conducted in two parts. In the first part, researchers will focus on understanding how safe the treatment is and determining the best dose to use. In the second part, they will look at how well the treatment works in controlling the cancer. Throughout the study, participants will be closely monitored for any side effects and to see how their cancer responds to the treatment.
In addition to patritumab deruxtecan, other medications may be used to help manage symptoms or side effects. These include dexamethasone, which is a type of steroid, and other medications that help prevent nausea and vomiting. The study aims to provide valuable information on the potential benefits and risks of using patritumab deruxtecan in treating these challenging pediatric cancers.



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