Ongoing Clinical Trials for Tissue Anoxia
There is currently 1 ongoing clinical trial investigating treatments for tissue anoxia. This trial is exploring the use of oxygen therapy to improve healing and reduce complications after ankle surgery in patients with additional health risks. Tissue anoxia refers to a condition where body tissues do not receive adequate oxygen supply.
Clinical trial locations
Study on Oxygen Therapy to Reduce Postoperative Complications in At-Risk Ankle Trauma Surgery Patients
This clinical trial is investigating whether nasal oxygen therapy can help reduce complications after ankle surgery in patients who face higher risks during recovery. The study is being conducted in France and focuses on individuals undergoing surgery for ankle injuries who have additional health concerns or particularly complex fractures.
Who can participate: To be eligible for this study, you must be over 18 years of age and have at least one risk factor that could affect healing after surgery. These risk factors include existing health conditions such as diabetes, smoking, peripheral neuropathy (nerve damage in the arms and legs), obstructive arterial disease of the lower limbs (poor blood flow in the legs), microangiopathy (damage to small blood vessels), or if you are receiving treatments like chemotherapy or corticosteroids that can affect healing. You may also qualify if you have a complex fracture, which includes dislocated bimalleolar fractures (breaks in two ankle bones), trimalleolar fractures (breaks in three ankle bones), fractures of the lower leg, tibial pilon fractures (breaks at the bottom of the shinbone), talus fractures (breaks in a small ankle bone), or open fractures where the bone pierces through the skin.
Who cannot participate: You will not be eligible if you do not have any of the specified health conditions or complex fractures mentioned above. The study also excludes patients who fall outside the required age range or who are considered part of a vulnerable population requiring special protection or care.
What the trial is studying: The main goal of this research is to determine whether providing oxygen through the nose can improve healing and reduce the rate of complications after ankle surgery. Researchers want to find out if this simple therapy can help prevent problems such as skin issues, infections, and poor healing of surgical scars in patients who are at higher risk. The study will compare two groups of patients: one receiving nasal oxygen therapy and one not receiving it, to see if there is a meaningful difference in recovery outcomes.
Treatment being tested: The investigational treatment is nasal oxygen therapy, which involves inhaling medicinal oxygen gas through a small, flexible tube placed in the nostrils. This therapy works by increasing the amount of oxygen available to body tissues, which is essential for cellular metabolism and repair processes. By improving oxygen levels in the blood, the therapy may aid in healing and reduce the risk of complications following surgery.
Participants will be monitored for up to six months after their surgery. During this time, the research team will check for any skin or infection problems, assess how well surgical scars are healing, measure pain levels, and evaluate overall quality of life. The study will also examine whether using oxygen therapy is cost-effective in these cases. Follow-up assessments occur at 24 hours, 48 hours, 3 weeks, 6 weeks, 12 weeks, and 24 weeks after surgery, with the final evaluation taking place at the end of the six-month period.
Summary
Currently, there is one ongoing clinical trial for tissue anoxia, located in France. This trial focuses specifically on patients undergoing ankle trauma surgery who have additional health risks that may complicate their recovery. The study is exploring nasal oxygen therapy as a potential way to improve healing outcomes and reduce postoperative complications in this at-risk population. The trial reflects a growing interest in using oxygen therapy to support tissue healing in patients with compromised oxygen delivery to their tissues, whether due to underlying health conditions or complex surgical needs.
