Ongoing Clinical Trials for Spinal Osteoarthritis
Currently, there is 1 ongoing clinical trial investigating pain management strategies for patients with spinal osteoarthritis undergoing spine surgery. This trial is exploring the use of Clonidine Hydrochloride to reduce the need for pain medication after surgical procedures.
Clinical trial locations
Clonidine Hydrochloride for Pain Management After Spine Surgery in Patients with Degenerative Spine Diseases
This clinical trial is taking place in Denmark and focuses on managing pain after spine surgery in patients with degenerative spine conditions. The study is testing whether a medication called Clonidine, given during surgery, can help reduce the amount of pain medication needed during recovery.
Main goal of the trial: The trial aims to determine how effective and safe Clonidine is in reducing the need for opioid pain medications after spine surgery. Researchers will monitor several important factors, including how much pain medication patients need in the first few hours and days after surgery, pain levels at rest and during coughing, sedation levels, and any nausea or vomiting. The study will also track how long patients stay in the recovery area and in the hospital overall, as well as pain medication use up to one month after surgery.
Investigational drug: Clonidine Hydrochloride is administered through an intravenous line directly into the bloodstream during surgery. It works by affecting certain parts of the brain to decrease pain signals, potentially helping patients feel less pain and require fewer painkillers after their operation. Clonidine is classified as an alpha-2 adrenergic agonist, a type of medication that can help calm the nervous system.
Who can participate: The trial is open to adults between 18 and 64 years old who are scheduled for spine surgery to treat degenerative spine diseases. Both men and women can participate. Patients should be able to make their own decisions and not be in vulnerable situations where they could be easily influenced.
Who cannot participate: The trial excludes patients with other serious health conditions that could interfere with the study, those who are pregnant or breastfeeding, and anyone with allergies to Clonidine or similar medications. Patients currently participating in another clinical trial, those with a history of drug or alcohol abuse, or those planning other surgeries soon cannot join. Additionally, individuals with uncontrolled high blood pressure, severe liver or kidney disease, a history of heart problems, or those unable to follow study procedures are not eligible.
The trial began recruiting participants in August 2023 and is scheduled to run until August 2025. Participants will receive either Clonidine or a placebo during their surgery, and their recovery will be carefully monitored to assess the medication’s effectiveness in managing post-surgical pain.
Summary
There is currently one active clinical trial addressing pain management for spinal osteoarthritis patients undergoing surgery. This trial, conducted in Denmark, represents an important investigation into alternative pain management strategies that may help reduce reliance on opioid medications following spine surgery. The focus on Clonidine Hydrochloride reflects ongoing efforts in the medical community to find safer and more effective ways to manage post-surgical pain in patients with degenerative spine conditions. Patients interested in participating should discuss eligibility with their healthcare provider, particularly regarding the age requirements and various health conditions that may affect participation.