Ongoing Clinical Trials for Skin Candida
This article provides information about ongoing clinical trials for skin candida, a fungal infection caused by the overgrowth of Candida species that affects warm, moist areas of the body. Currently, there is 1 clinical trial actively recruiting patients to test new treatments for moderate to severe cases of this condition.
Clinical trial locations
Study Comparing Effects of Ointments with Clotrimazole and Betamethasone Dipropionate for Patients with Moderate to Severe Skin Yeast Infections
This trial is being conducted in Germany and focuses on treating moderate to severe skin infections caused by yeast fungi. The study compares the effectiveness and safety of three different ointments over a two-week treatment period.
Main focus and goal: The trial aims to determine which ointment is most effective in reducing symptoms of candidiasis of the skin and to ensure that the treatments are safe for patients. Researchers will monitor how symptoms change over time, whether the infection returns after treatment, and how participants feel about the treatment’s success. The study involves several visits where both investigators and participants evaluate the skin condition.
Investigational drugs: The trial tests two main ointments. Mecloderm Ointment is a new treatment containing clotrimazole (which fights fungal infections) and betamethasone dipropionate (which reduces inflammation and itching). Lotricomb Ointment is an existing medication with the same active ingredients, used as a reference for comparison. A third ointment without any active substances (called a vehicle) is also used to help determine the effectiveness of the active treatments.
Who can participate – inclusion criteria:
- Adults aged 18 years or older
- Diagnosed with candidiasis of the skin based on visible symptoms
- Positive test result from a skin swab showing at least a moderate number of fungi under a microscope
- Total score of clinical symptoms (redness, fluid discharge, burning sensation, and skin softening) of 7 or higher
- Moderate severity of redness and fluid discharge (score of 2 or higher)
- Must provide written consent after being fully informed about the study
- Women who can have children must use highly effective birth control and have a negative pregnancy test before starting
Who cannot participate – exclusion criteria:
- Patients allergic to any ingredients in the ointments
- Patients with other skin infections not caused by Candida fungus
- Pregnant or breastfeeding women
- Patients who have used similar treatments recently
- Patients with certain medical conditions that might interfere with the study or pose safety risks
- Patients unable to follow study instructions or attend required visits
Summary
Currently, there is one active clinical trial for skin candida, located in Germany. This trial focuses on moderate to severe cases of the infection and compares two ointments containing the same active ingredients: clotrimazole (an antifungal) and betamethasone dipropionate (an anti-inflammatory steroid). The study is designed to determine whether a new formulation (Mecloderm) works as well as or better than an established treatment (Lotricomb). The trial runs for two weeks and includes careful monitoring to assess both effectiveness and safety. This research is important for patients with moderate to severe skin candida who need effective treatment options to reduce inflammation, itching, and fungal overgrowth.