Ongoing Clinical Trials for Bartonellosis
There is currently 1 ongoing clinical trial investigating treatment options for Bartonellosis, also known as Cat Scratch Disease. This trial is exploring the effectiveness of antibiotic treatments for managing swollen and infected lymph nodes caused by the condition.
Clinical trial locations
Study on Gentamicin and Azithromycin for Treating Lymph Node Infection in Cat Scratch Disease Patients
This clinical trial is investigating a new treatment approach for people with suppurative lymphadenitis caused by cat scratch disease. Suppurative lymphadenitis refers to swollen lymph nodes that have become filled with pus due to infection. The study is testing whether injecting an antibiotic called gentamicin directly into the affected lymph nodes can help improve the condition more effectively than standard treatment alone.
Inclusion criteria: To participate in this trial, you must be an adult aged 18 years or older and willing to provide informed consent after understanding the study details. You need to have suppurated cat scratch disease lymphadenitis, which means your lymph nodes are swollen and filled with pus. This diagnosis must be confirmed through an ultrasound test and blood tests showing positive results for specific antibodies against the bacteria that causes the condition. Additionally, you must be affiliated with the French Social Security System, meaning you are part of the healthcare system in France.
Exclusion criteria: You cannot participate if you have not been diagnosed with this specific bacterial infection. The trial specifically focuses on patients with suppurative lymphadenitis related to cat scratch disease. You must also be willing to take oral azithromycin as part of the treatment. Patients who fall outside the specified age range or are considered part of a vulnerable population requiring special protection are also excluded from the study.
Trial focus: The main goal of this study is to determine whether injecting gentamicin directly into infected lymph nodes can lead to better outcomes for patients over a 28-day period. Researchers will monitor the reduction in size of the swollen lymph nodes using ultrasound imaging, aiming for at least an 80% reduction in volume by day 28. The trial will also assess whether this treatment reduces pain and decreases the need for additional medical procedures such as needle drainage or surgery. Safety of the gentamicin injection will be carefully monitored throughout the study.
Investigational drugs: The trial uses two antibiotics. Gentamicin is an aminoglycoside antibiotic that is injected directly into the affected lymph nodes to target the infection more effectively. It works by stopping bacteria from making proteins they need to survive. Azithromycin is a macrolide antibiotic taken orally in tablet form at a dose of 250 mg. It also works by interfering with bacterial protein production, helping to stop the growth of bacteria. All participants will receive azithromycin as standard treatment, while some will receive the gentamicin injection and others will receive a placebo injection for comparison.
The study includes several visits where healthcare providers will assess your progress through ultrasound examinations and evaluate changes in pain levels and lymph node size. Follow-up visits are scheduled at day 7 and day 28 after treatment begins. The trial is expected to be completed by December 31, 2025.
Summary
Currently, there is one active clinical trial focused on improving treatment outcomes for Bartonellosis, specifically for patients with suppurative lymphadenitis. This trial is being conducted in France and represents an important effort to develop more targeted treatment approaches for this condition. The study is investigating whether direct injection of antibiotics into infected lymph nodes can provide better results than standard oral antibiotic treatment alone. Both gentamicin and azithromycin are being studied as treatment options, with researchers carefully monitoring their effectiveness and safety. This trial may provide valuable insights into better management strategies for patients experiencing painful and swollen lymph nodes due to cat scratch disease.
