ECRI-trials B.V.

Cardiovascular Disease

The research portfolio is centered on acute myocardial infarction, with attention to post-event coronary artery disease and the management of residual vascular risk.

  • Myocardial infarction
  • Coronary atherosclerosis
  • Atherosclerotic burden

Clinical activity in this area focuses on anti-inflammatory and cardiometabolic approaches relevant to patients recovering from an acute coronary event.

Vascular Imaging and Plaque Assessment

Interest extends to the evaluation of atheroma burden and structural changes in the coronary vessels, reflecting a focus on measurable markers of vascular disease.

  • Percent atheroma volume
  • Coronary plaque
  • Vascular remodeling

This area connects clinical research with the assessment of plaque progression and plaque stabilization in patients with established cardiovascular disease.

Secondary Prevention After Acute Coronary Events

The sponsor’s research interest includes therapies used alongside standard of care after acute coronary syndrome, with emphasis on reducing ongoing vascular injury.

  • Post-infarction care
  • Residual inflammatory risk
  • Secondary cardiovascular prevention

These studies align with clinical needs in the early period following myocardial infarction, where prevention of further coronary events remains a key therapeutic concern.

Inflammation-Targeted Therapeutics

Research activity also reflects interest in cytokine-mediated inflammation and related pathways that contribute to atherosclerotic disease in the setting of cardiovascular inflammation.

  • Inflammatory biomarkers
  • Immune modulation
  • Atherosclerosis-related inflammation

The therapeutic focus is relevant to interventions aimed at limiting inflammatory drivers of coronary artery disease after an acute myocardial infarction.

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Matched clinical trials

  • Study of ziltivekimab compared to placebo in patients with acute heart attack to evaluate its effects on coronary artery plaque reduction

    Recruiting

    3 1
    Investigated diseases:
    Investigated drugs:
    Austria Denmark Italy The Netherlands Spain