Neurodegenerative disease and motor neuron disorders
Research activity includes amyotrophic lateral sclerosis and related neurodegenerative conditions affecting disease progression and symptom burden.
- Amyotrophic lateral sclerosis
- Motor neuron disease
- Symptom progression
Clinical interest extends to immune-modulating and disease-modifying strategies for progressive neurologic decline.
Dementia and cognitive impairment
The sponsor is active across multiple forms of dementia, including Alzheimer disease, autoimmune dementia, and other cognitive syndromes with early, late, or unspecified onset.
- Alzheimer disease dementia
- Autoimmune dementia
- Cognitive impairment
Its portfolio also covers atypical, mixed, and disorder-specific dementia presentations linked to underlying neurologic disease.
Vascular and mixed dementia
Several studies focus on vascular dementia subtypes, including multi-infarct dementia, subcortical vascular dementia, and mixed cortical-subcortical forms.
- Vascular dementia
- Multi-infarct dementia
- Subcortical vascular dementia
These areas reflect interest in cognitive disorders associated with cerebrovascular injury and overlapping neurodegenerative pathology.
Protein-mediated and immune-related neurologic disease
Research also spans dementia linked to Huntington disease, Parkinson disease, Creutzfeldt-Jakob disease, Pick disease, and HIV-associated dementia.
- Huntington disease dementia
- Parkinson disease dementia
- Creutzfeldt-Jakob disease dementia
These topics indicate involvement in cognitive complications arising from protein aggregation, prion disease, and chronic immune or infectious neurologic conditions.
Neuroimaging and diagnostic assessment
One area of interest is amyloid PET imaging in the diagnostic work-up of dementia, with attention to morbidity and care-related outcomes.
- Amyloid PET
- Dementia diagnostics
- Care-related outcomes
This aligns with a broader focus on improving identification of Alzheimer-related pathology and other causes of cognitive decline.
