Gastrointestinal cancers and pancreatic malignancies
Research activity centers on gastric cancer, gastroesophageal junction adenocarcinoma, metastatic pancreatic adenocarcinoma, and related advanced solid tumors, with emphasis on tumors defined by CLDN18.2 expression and HER2-negative disease.
- Gastric adenocarcinoma
- Gastroesophageal junction adenocarcinoma
- CLDN18.2-positive tumors
- Metastatic pancreatic adenocarcinoma
The portfolio also includes studies in locally advanced unresectable and metastatic upper gastrointestinal disease.
Hematologic malignancies
Clinical research includes acute myeloid leukemia with FLT3 mutation, including FLT3-ITD disease in newly diagnosed, relapsed, and refractory settings, as well as treatment approaches for patients not eligible for intensive induction therapy.
- Acute myeloid leukemia
- FLT3-mutated AML
- Relapsed or refractory leukemia
- Newly diagnosed AML
These studies extend to younger populations and to combinations with other cancer therapies.
Genitourinary cancers and prostate cancer
The sponsor funds work in prostate cancer, including metastatic castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer, alongside studies in locally advanced and metastatic urothelial cancer.
- Prostate cancer
- Metastatic castration-resistant prostate cancer
- Metastatic hormone-sensitive prostate cancer
- Urothelial cancer
Additional interest is shown in androgen receptor pathway-related treatment settings and broader genitourinary oncology.
Renal, bladder, and ocular disorders
Non-oncology research includes anemia associated with chronic kidney disease, neurogenic detrusor overactivity, and geographic atrophy, reflecting activity across kidney, bladder, and retinal disease areas.
- Chronic kidney disease-related anemia
- Neurogenic detrusor overactivity
- Geographic atrophy
- Retinal degeneration
These programs span both adult and pediatric populations.
Allergy, vasomotor symptoms, and supportive care
The clinical portfolio also covers allergy to house dust mites, moderate to severe vasomotor symptoms, and hot flushes associated with endocrine therapy in hormone receptor-positive breast cancer.
- House dust mite allergy
- Vasomotor symptoms
- Hot flushes
- Breast cancer supportive care
Related studies include symptom management and quality-of-life concerns across oncology and non-oncology settings.
